Thursday, December 26, 2024

Transhumanism: Evolution Beyond Human Limitations

 Transhumanism: Evolution Beyond Human Limitations

Introduction

Transhumanism, a term derived from "transcend" and "human," represents a movement aimed at enhancing the human condition through advanced technologies. The term was popularized by Julian Huxley in 1957, who envisioned humanity evolving beyond its current physical and mental limitations. Over time, transhumanism has grown into a multidisciplinary field encompassing philosophy, science, ethics, and technology.


Origins of the Term

The word “transhumanism” is a combination of the Latin prefix "trans," meaning "beyond" or "across," and "humanism," which emphasizes the value and agency of human beings. Huxley, a biologist and philosopher, introduced the concept in his essay, "Transhumanism," where he described it as the belief in humanity’s potential to transform itself through science and reason.


Major Proponents

1.   Julian Huxley:

o    Introduced the term and laid its philosophical groundwork.

2.   Ray Kurzweil:

o    A leading advocate for the "Singularity," the point where artificial intelligence surpasses human intelligence.

o    Author of "The Singularity is Near" and a proponent of life-extension technologies.

3.   Nick Bostrom:

o    Philosopher and founder of the Future of Humanity Institute at the University of Oxford.

o    Explores existential risks and ethical implications of transhumanism.

4.   Natasha Vita-More:

o    Designer and futurist advocating for human enhancement and life extension.

5.   Elon Musk (indirectly):

o    Through initiatives like Neuralink, Musk explores brain-computer interfaces that align with transhumanist goals.


Necessities Driving Transhumanism

1.   Medical Advancements:

o    Overcoming diseases and disabilities through genetic engineering, prosthetics, and bio-enhancements.

2.   Longevity:

o    Extending human lifespan and improving quality of life.

3.   Cognitive Enhancement:

o    Enhancing mental capabilities to solve complex global challenges.

4.   Space Exploration:

o    Preparing humanity for extraterrestrial living by augmenting physical and psychological resilience.

5.   Ethical Imperatives:

o    Addressing inequalities and improving human welfare through equitable access to enhancements.


Advantages of Transhumanism

1.   Health and Longevity:

o    Advanced therapies could eradicate diseases and significantly extend life expectancy.

2.   Enhanced Abilities:

o    Cognitive and physical enhancements could unlock untapped human potential.

3.   Economic Growth:

o    Innovations in biotechnology and AI could drive new industries and opportunities.

4.   Improved Quality of Life:

o    Technologies like brain-computer interfaces could improve mobility and communication for people with disabilities.

5.   Exploration and Innovation:

o    Enhanced humans could better adapt to extreme environments, aiding space exploration and colonization.


Disadvantages and Ethical Concerns

1.   Social Inequality:

o    Enhancements may be accessible only to the wealthy, exacerbating societal divides.

2.   Loss of Identity:

o    Critics argue that radical enhancements could erode what it means to be human.

3.   Existential Risks:

o    Misuse of advanced technologies could lead to catastrophic outcomes, such as autonomous weapons or AI domination.

4.   Moral and Religious Opposition:

o    Many view transhumanism as unnatural or a challenge to divine authority.

5.   Unintended Consequences:

o    Genetic modifications or AI integration might produce unforeseen and irreversible effects.


Threats Posed by Transhumanism

1.   Technological Overreach:

o    Rushing into enhancements without understanding long-term impacts.

2.   Ethical Dilemmas:

o    Questions of consent, especially for unborn generations subjected to genetic editing.

3.   Global Conflicts:

o    Nations could compete aggressively for technological supremacy, leading to geopolitical instability.

4.   Erosion of Privacy:

o    Brain-computer interfaces and surveillance technologies could infringe on personal freedoms.


Key Areas of Focus in Transhumanism

1.   Artificial Intelligence:

o    Creating machines that can think, learn, and potentially surpass human intelligence.

2.   Genetic Engineering:

o    CRISPR and other tools to modify DNA, curing diseases and enhancing traits.

3.   Nanotechnology:

o    Using molecular-scale technologies for medical and structural applications.

4.   Cybernetics:

o    Integrating technology with the human body to improve or restore functions.


Case Studies and Examples

1.   CRISPR Gene Editing:

o    Real-world applications include curing genetic disorders like sickle cell anemia.

2.   Neuralink:

o    Elon Musk’s project aims to create direct interfaces between the human brain and computers.

3.   Exoskeletons:

o    Wearable robotics that enhance physical strength and mobility.


Conclusion

Transhumanism presents humanity with unprecedented opportunities and challenges. While it offers the promise of overcoming biological limitations and improving quality of life, it also raises profound ethical, social, and existential questions. To harness its potential responsibly, society must engage in inclusive dialogue, establish ethical frameworks, and ensure equitable access to advancements. As we stand on the brink of a transhumanist future, the choices we make today will shape the trajectory of human evolution for generations to come.

 

The interrelation between Artificial Intelligence (AI) and Transhumanism stems from their mutual focus on enhancing human capabilities and overcoming biological and cognitive limitations. While transhumanism is a philosophical and technological movement advocating for human evolution through technology, AI serves as a pivotal tool in achieving many of its aspirations. Below is a detailed exploration of this relationship:


1. Core Philosophical Alignment

Both AI and transhumanism share the belief that human limitations—whether physical, cognitive, or social—can and should be overcome through technological means.

  • Transhumanism's Vision: Seeks to extend life, enhance intelligence, and improve physical and mental performance.
  • AI's Role: Acts as a catalyst by providing tools for cognitive augmentation, decision-making, and problem-solving that surpass human capabilities.

2. AI as a Key Enabler of Transhumanist Technologies

AI technologies are foundational to many transhumanist ambitions:

  • Brain-Computer Interfaces (BCIs): AI-driven BCIs, like Neuralink, aim to merge human consciousness with machines, allowing for cognitive enhancement and seamless interaction with digital systems.
  • Human Longevity: AI is used in bioinformatics and personalized medicine to decode the aging process and develop treatments that extend life.
  • Cognitive Augmentation: AI-powered tools such as natural language processors and decision-making algorithms enhance human intelligence.
  • Prosthetics and Robotics: AI enables the development of advanced prosthetics and exoskeletons, improving physical abilities and mobility.

3. Shared Technologies

AI and transhumanism intersect in several cutting-edge technologies:

  • Genetic Engineering: AI algorithms analyze genetic data to identify modifications that could enhance human traits.
  • Virtual Reality (VR) and Augmented Reality (AR): Used for creating immersive experiences and training, aligning with transhumanist goals of expanding human experience.
  • Automation and Robotics: AI-driven robots and systems help replace or augment human labor, fitting the transhumanist ethos of transcending biological constraints.

4. Ethical and Philosophical Challenges

While their alignment offers transformative potential, the interplay between AI and transhumanism raises significant ethical concerns:

  • Loss of Human Identity: Integrating AI into human biology could blur the line between humans and machines, challenging the concept of humanity.
  • Inequality: Access to AI-enhanced capabilities might create a new class divide between enhanced and non-enhanced individuals.
  • Autonomy and Control: AI systems integrated into human bodies or decision-making processes could compromise individual autonomy.
  • Existential Risks: The pursuit of superintelligent AI aligns with transhumanist goals but could lead to unintended consequences if AI systems surpass human control.

5. Prominent Figures and Movements

Several thinkers and organizations advocate for the convergence of AI and transhumanism:

  • Ray Kurzweil: A leading proponent of the Singularity, Kurzweil envisions AI as a key to achieving transhumanist goals, such as mind uploading and immortality.
  • Nick Bostrom: Author of Superintelligence, Bostrom explores the risks and potential of AI within a transhumanist framework.
  • Elon Musk: Through ventures like Neuralink, Musk advocates for merging human intelligence with AI to stay relevant in the age of machine intelligence.

6. Potential Advantages

  • Enhanced Problem-Solving: AI can augment human cognitive abilities, enabling better decision-making and creativity.
  • Extended Lifespan: AI-driven medical advancements could significantly increase human longevity.
  • Universal Access to Knowledge: AI can democratize access to education and information, aligning with transhumanist ideals of self-improvement.

7. Threats and Criticisms

  • Ethical Dilemmas: Integrating AI into human life could lead to unforeseen moral quandaries.
  • Dependence on Technology: Over-reliance on AI might erode natural human skills and resilience.
  • Power Concentration: The development of AI technologies could centralize power in the hands of a few corporations or governments.

Conclusion

The relationship between AI and transhumanism represents a profound convergence of technology and philosophy. While AI serves as a practical tool to achieve transhumanist ideals, it also amplifies the ethical, social, and existential questions surrounding the future of humanity. The dialogue between these two domains will likely shape the trajectory of human evolution in the coming decades.

Monday, December 2, 2024

4 Things to learn about Sex : Sperm and testosterone, Orgasm, G Spot,

 Orgasm and G Spot 
భావప్రాప్తి అంగజం

4 Things to learn about Sex : Sperm and testosterone, Orgasm,  G Spot, 

An orgasm is the height or peak of sexual arousal when the body releases sexual tension and pressure. It involves very intense feelings of pleasure in your genitals and throughout your body. An orgasm usually lasts a few seconds and feels very good.
Women who orgasm are much more satisfied with encounters than those who do not. Indeed, women are five times more likely to enjoy a sexual encounter if they orgasmed during the experience [20]. In sum, orgasm is strongly related to sexual satisfaction, even though women indicate it is not important for them.17 Aug 2023
భావప్రాప్తి అంగజం
What is the G-spot, and where is it?
In 1950, German gynecologist Ernst Gräfenberg described a distinct erotic region on the inner upper wall of the vagina, or the G-spot. Since then, the G-spot has remained the subject of scientific and sexual controversy.
Some females report experiencing immense pleasure from the stimulation of this spot. However, others have reported frustration from their inability to find it or believe they do not have a G-spot.
Finding the G-spot can increase some females’ sexual pleasure and give couples a fun sexual challenge to pursue.
However, it is important to note that people who cannot find the G-spot or who do not want to try to find it can still enjoy gratifying and pleasurable sex.
A note about sex and gender
Sex and gender exist on spectrums. This article will use the terms “male,” “female,” or both to refer to sex assigned at birth.
Everything You Need to Know About the G Spot
What is it?
Finding it
Positions to stimulate
Finding what works
The G spot is not a separate and specific part of the anatomy but part of the larger clitoral network. Finding what works for you can take time — and that’s OK.
Orgasms can help reduce stress, improve your skin, and make you feel, well, great. However, vaginal orgasms — especially those achieved through penetration — can be just as elusive as the mysterious G spot.
It’s relatively uncommon for people with a vagina to orgasm through intercourse alone. And according to a 2017 study, only about 18% of women achieve orgasm through penetration alone — meaning no hands, mouth, or toys needed.
More often than not, clitoral stimulation is required, or at least beneficial, when it comes to orgasming during sex.
However, even if you haven’t experienced an orgasm from vaginal penetration, that doesn’t mean it’s impossible. Some believe the G spot may be the key to vaginal orgasm during penetration. But some researchersTrusted Source believe that vaginal orgasms don’t exist, so it can be difficult to separate fact from fiction.
What is the G spot?
You’ve probably heard of the G spot, along with how it’s the “key” to achieving an earth-shattering vaginal orgasm. But is it real? Honestly, it’s complicated.
Known as the Gräfenberg spot, the G spot was introduced by Dr. Beverly Whipple after she discovered that using a “come here” motion along the inside of the vagina produced a physical response. She believed this region could be the key to achieving orgasm during penetration.
However, it’s important to clarify that the G spot isn’t a distinct part of your anatomy. In a 2017 study, researchers attempted to find the G spot only to come up empty-handed.
Instead of being a separate spot in your vagina, the G spot is part of your clitoral network. This means that when you’re stimulating the G spot, you’re stimulating part of the clitoris, which is much larger than we’re led to believe. The pea-sized nub where the inner labia meet is only the tip of the clitoris and divides into two “roots” that can be about 4 inches long.
Plus, this region can vary from person to person which explains why it can often be difficult to locate. However, once stimulated, the G spot can cause squirting (yes, it’s real) and help reach vaginal orgasm.
How can you find it?
Finding the G spot can be difficult, especially since it’s not actually on any map of the human body. That doesn’t mean it’s impossible. Instead of searching for it during partnered sexual activity, it’s easier to locate the G spot through self-exploration.
If you’re looking to find your G spot, start by relaxing. As you explore your body, do what feels best to you. When you’re ready, begin massaging the opening to your vagina before inserting your fingers or a sex toy.
Then, using your fingers or a toy, lift upward toward your belly button in a “come hither” motion. Remember, you’re not trying to hit a specific button but instead finding what feels best for you in that general region.
Repeat the motion as the sensation builds, and — instead of an in-and-out movement — experiment with keeping your attention focused on this internal area.
Like other erogenous zones, preferences can vary from person to person. A 2016 reviewTrusted Source emphasized that orgasms are not one-size-fits-all, so there’s no right or wrong way to orgasm.
Not everyone will find satisfaction through G spot stimulation, and that’s fine too. Remember that masturbation is a completely normal and healthy way to feel good in your body. By taking time to explore your preferences, you can also use that information to instruct your partner on what you enjoy most during sex.
The best sex positions to stimulate the G spot
You can experiment with G spot stimulation with a partner, using fingers, a penis, or a sex toy designed for penetration. Try positions that allow you a little more control over your movements so you can figure out what types of stimulation you enjoy most. While many sex positions can help you achieve this, here are three to try.
Rider
Some people refer to this as the “cowgirl” position. Have your partner lay on their back, then climb on top and straddle them. This position allows you complete control over the rhythm, depth, and angle of penetration so you can focus on finding your G spot.
Instead of bobbing up and down, try moving back and forth to stimulate the G spot region against your inner vaginal wall. Mixing it up can also help, so don’t be afraid to experiment with different speeds and angles.
Doggy style
Doggy style is another great way to achieve deeper penetration during sex. It’s easy to vary the angle to hit your G spot.


Start on your hands and knees with your partner behind you. During penetration, try leaning down on your forearms or pushing your hips backward to change the angle until you find the position that works best for you.


If you’d like, you can try a different variation by lying flat on your stomach with your legs hanging off the edge of the bed, allowing your partner to stand behind you and penetrate from there.


Closed missionary position
This variation on the classic missionary position allows for greater stimulation without the depth of penetration.


You’ll start on your back in missionary position before moving your legs together. Then, your partner’s legs should straddle yours, allowing a tighter squeeze.


While this shallow penetration might not hit as deep, it does create a tighter feeling — and more increased friction against your G spot — which might be the perfect way to help you reach orgasm.


Find what works for you
Despite what you might see in movies, sex isn’t always quick and easy. Often, we are led to believe that sex is shameful, which can make it harder to achieve orgasm and sexual satisfaction.


Don’t be afraid to take charge of your sex life and find what you like. If that means you can find your G spot and rock it, good for you. If not? That’s great too. No rule says there’s one way to orgasm, and — for most people with internal genitals — it’s OK to prefer a combination of efforts. Finding what works for you can take time, so be patient.


The most important thing is that you’re satisfied. Exploring your body and your sexual preferences is a great step in making sure you have a happy, safe, and pleasurable sex life. You should never feel ashamed of figuring out what you like. After all, everyone deserves to have great sex.


Sperm and testosterone are distinct entities with unique structures and functions, though both are vital to male reproductive health and functionality. Here’s a breakdown:


1. Sperm
Definition:


Sperm are male reproductive cells, produced in the testes through a process called spermatogenesis.
Structure:


Composed of three main parts:
Head: Contains genetic material (DNA) that combines with the female egg during fertilization.
Midpiece: Packed with mitochondria to provide energy for movement.
Tail (Flagellum): Enables motility to swim towards the egg.
Function:


The primary function of sperm is fertilization—carrying genetic material to the female egg to create a zygote.
Sperm quality and motility are critical factors in male fertility.
Lifespan:


In the male body: Sperm are constantly produced but take around 74 days to mature.
Outside the body: Sperm can survive up to 5 days in the female reproductive tract under optimal conditions.
2. Testosterone
Definition:


Testosterone is a steroid hormone belonging to the androgen group, produced primarily in the testes (in Leydig cells) and in small amounts by the adrenal glands.
Structure:


Testosterone is a chemical compound with the molecular formula C19H28O2.
Function:


Testosterone’s role spans beyond reproduction:
Development of Male Characteristics:
Promotes the growth of secondary sexual traits like facial hair, a deeper voice, and increased muscle mass.
Sperm Production:
Testosterone plays a key role in spermatogenesis, aiding the maturation of sperm cells.
Libido: Regulates sex drive and energy levels.
Bone and Muscle Health: Maintains bone density and supports muscle growth.
Mood Regulation: Impacts cognitive functions and mood stability.
Lifespan and Regulation:


Testosterone levels fluctuate daily and decrease with age. The hormone is regulated by the hypothalamic-pituitary-gonadal (HPG) axis.
Key Differences
Aspect Sperm Testosterone
Type A cell A hormone
Produced in Testes (seminiferous tubules) Testes (Leydig cells)
Function Fertilization and reproduction Regulation of male traits and reproduction
Physical Structure Cellular structure with head, midpiece, and tail Steroid chemical compound
Role in Reproduction Direct carrier of genetic material Indirect support by enabling sperm production
Relationship Between Sperm and Testosterone
Testosterone is crucial for spermatogenesis:


It stimulates Sertoli cells in the testes, which nourish developing sperm.
Low testosterone levels can lead to reduced sperm production and infertility.
Understanding the distinction and interdependence between sperm and testosterone underscores their collective importance in male reproductive health.

Tuesday, November 26, 2024

Ministry of Information Technology, Electronics and Communication

 Ministry of Information Technology, Electronics and Communication

Minister of Information Technology or simply referred to as the IT Minister, is officially known as the Minister of Information Technology, Electronics and Communications. The current IT Minister of Andhra Pradesh is Nara Lokesh.

https://apit.ap.gov.in/#/

https://apit.ap.gov.in/#/contactus

4th Block, 1st Floor, Room No:269, A.P Secretariat, Velagapudi

Email: prlsecy_itc[at]ap[dot]gov[dot]in

Sri Nara Lokesh Hon’ble Minister for ITE&C 0863-2444505 4th Block, Room No:208, First Floor, A.P Secretariat, Velagapudi.

Email: -----

Dr. N.Yuvaraj, IAS Secretary to Government (FAC) 0863-2444243 4th Block, 1st Floor, Room No:269, A.P Secretariat, Velagapudi

Email: prlsecy_itc@ap.dot]gov[dot]in

AP IT Policy CM Chnadrababu

 ఐటిలో మేటి 

CM Chandrababu : ఐటీలో మేటి

ABN , Publish Date - Nov 27 , 2024 | 03:47 AM


రాష్ట్రాన్ని ఇన్ఫర్మేషన్‌ టెక్నాలజీ (ఐటీ) రంగంలో ఉన్నత స్థానంలో నిలిపేలా పలు కార్యక్రమాలకు ముఖ్యమంత్రి నారా చంద్రబాబునాయుడు ఆమోదం తెలిపారు. సాంకేతిక రంగంలో వస్తున్న మార్పులకు అనుగుణంగా చేపట్టాల్సిన పనులపై అధికారులకు సూచనలు చేశారు.

రాష్ట్రంలో ఐటీ అభివృద్ధికి పలు కార్యక్రమాలు

అమరావతిలో డీప్‌ టెక్నాలజీ ఐకానిక్‌ భవనం

2029 నాటికి 5 లక్షల ఐటీ వర్క్‌ స్టేషన్లు

ఐటీ డెవలపర్లకు కేటగిరీల వారీగా రాయితీలు

జోనల్‌ హబ్‌లతో ఐఐటీల అనుసంధానం

యువతలో నైపుణ్యాన్ని పెంచే కార్యక్రమాలు

పలు వర్గాల స్టార్ట్‌పలకు 25 లక్షల వరకు సబ్సిడీ

కొత్త ఐటీ పాలసీకి సీఎం చంద్రబాబు ఆమోదం

అమరావతి, నవంబరు 26(ఆంధ్రజ్యోతి): రాష్ట్రాన్ని ఇన్ఫర్మేషన్‌ టెక్నాలజీ (ఐటీ) రంగంలో ఉన్నత స్థానంలో నిలిపేలా పలు కార్యక్రమాలకు ముఖ్యమంత్రి నారా చంద్రబాబునాయుడు ఆమోదం తెలిపారు. సాంకేతిక రంగంలో వస్తున్న మార్పులకు అనుగుణంగా చేపట్టాల్సిన పనులపై అధికారులకు సూచనలు చేశారు. నూతన టెక్నాలజీ ప్రయోజనాలను రాష్ట్రం అందిపుచ్చుకునేందుకు పలు రాయితీలు ప్రకటించారు. 

ఐటీ రంగానికి ఇవ్వాల్సిన ప్రోత్సాహకాలు, ఐటీ డెవలపర్లకు ఇచ్చే సబ్సిడీలు ఎలా ఉండాలో కూడా స్పష్టం చేశారు. వెలగపూడి సచివాలయంలో మంగళవారం కొత్త ఐటీ పాలసీ 2024-29పై ముఖ్యమంత్రి చంద్రబాబు సమీక్షించి.. గ్రీన్‌సిగ్నల్‌ ఇచ్చారు. ఈ సందర్భంగా ఐదేళ్లలో చేపట్టాల్సిన కార్యక్రమాలు, ఉద్యోగ కల్పన, ఐటీ రంగానికి సదుపాయాలు, రాయితీలపై అధికారులకు ఆదేశాలు ఇచ్చారు. రాజధాని అమరావతితో పాటు రాష్ట్ర వ్యాప్తంగా చేపట్టాల్సిన కార్యక్రమాలపై స్పష్టతనిచ్చారు. ఈ సందర్భంగా ఐటీ పాలసీపై మానవనరుల అభివృద్ధి, ఐటీ, ఎలకా్ట్రనిక్‌ శాఖ మంత్రి నారా లోకేశ్‌ తన అభిప్రాయాలను వెల్లడించారు.

భవిష్యత్‌ అంతా డీప్‌ టెక్‌దే

రాజధాని నగరం అమరావతిలో డీప్‌ టెక్నాలజీ ఐటీ ఐకానిక్‌ భవనాన్ని నిర్మించాలని అధికారులను సీఎం చంద్రబాబు ఆదేశించారు. ఈ భవన నిర్మాణానికి సంబంధించిన కార్యాచరణ ప్రణాళికలను సిద్ధం చేయాలన్నారు. యువత భవిష్యత్తు అంతా డీప్‌ టెక్నాలజీ, ఆర్టిఫిషియల్‌ ఇంటెలిజెన్స్‌ లాంటి నూతన టెక్నాలజీలపైనే ఆధారపడి ఉందని చెప్పారు. అదేవిధంగా ప్రస్తుతం డీప్‌ టెక్నాలజీతో కలుగుతున్న ప్రయోజనాలను అందిపుచ్చుకునేలా ఆ ఐకానిక్‌ భవనం ఉండాలని అధికారులను సీఎం చంద్రబాబు ఆదేశించారు.

2029 నాటికి ఐదు లక్షల వర్క్‌ స్టేషన్లు

ఐటీ రంగానికి ఇవ్వాల్సిన ప్రోత్సాహకాలపై కొత్త ఐటీ పాలసీపై సమీక్షలో సీఎం చంద్రబాబు స్పష్టత ఇచ్చారు. 2029కల్లా రాష్ట్రంలో ఐదు లక్షల వర్క్‌ స్టేషన్లు, 2034కల్లా పది లక్షల వర్క్‌ స్టేషన్లు ఏర్పాటు చేయడం లక్ష్యంగా నిర్దేశించుకోవాలని పనిచేయాలన్నారు. కో-వర్కింగ్‌ స్పేస్‌లు, కార్యాలయాల సముదాయాలు నిర్మాణానికి అవసమైన భూములు సబ్సిడీపై లీజుకివ్వడంతో పాటు సింగిల్‌ విండో విధానంలో మౌలిక వసతుల కల్పనపై దృష్టి సారించాలని సీఎం సూచించారు. ఐటీ సంస్థలకు ఇండస్ట్రియల్‌ పవర్‌ టారీఫను అమలు చేయాలని స్పష్టం చేశారు. స్టార్టప్‌ పాలసీలో భాగంగా ఎస్సీ, ఎస్టీ, బీసీ, మైనారిటీ, మహిళలకు రూ. 25 లక్షల వరకు మూలధన సబ్సిడీని ఇవ్వాలని స్పష్టం చేశారు.

ఐఐటీలతో ఇన్నోవేషన్‌ అనుసంధానం

అమరావతిలో స్థాపించే రతన్‌టాటా ఇన్నోవేషన్‌ హబ్‌కు ఐఐటీలను అనుసంధానం చేయాలని ఈ సందర్భంగా ముఖ్యమంత్రి చంద్రబాబు చెప్పారు. రాష్ట్రంలో ఐదు జోనల్‌ ఇన్నోవేషన్‌ హబ్‌లను ఏర్పాటుపైనా ఈ ఉన్నతస్థాయి సమావేశంలో దిశానిర్దేశం చేశారు. సెంట్రల్‌ ఆంధ్ర, రాయలసీమ, దక్షిణాంధ్ర, గోదావరి, ఉత్తరాంధ్ర ఇలా ఐదు ప్రాంతాల్లోనూ జోనల్‌ హబ్‌లను ఏర్పాటు చేయాలని.. వాటికి ప్రధాన కేంద్రంగా అమరావతిలోని రతన్‌ టాటా ఇన్నోవేషన్‌ హబ్‌ ఉంటుందని చంద్రబాబు వెల్లడించారు. ఆ జోనల్‌ హబ్‌లకు దేరీశంలోని 25 ఐఐటీలను అనుసంధానం చేయాలని ఆదేశించారు.

ఉద్యోగ కల్పనే లక్ష్యం

ఐటీ పాలసీ అమలులో భాగంగా నెలవారీ ఉద్యోగ కల్పనే లక్ష్యంగా సమీక్షలను నిర్వహిస్తామని ముఖ్యమంత్రి చంద్రబాబు తెలిపారు. పాలసీ ప్రకటన తర్వాత వర్క్‌స్టేషన్ల ఏర్పాటుకు అనువైన ప్రదేశాలను జిల్లా కలెక్టర్లు కూడా గుర్తించాలన్నారు. గ్రామ, వార్డు సచివాలయ ఉద్యోగుల సహకారంతో రాష్ట్రంలో ఎంతమంది వర్క్‌ ఫ్రమ్‌ హోం చేస్తున్నారో గుర్తించాలన్నారు. తద్వారా అయా ప్రాంతాల్లో వర్క్‌స్టేషన్ల ఏర్పాటుపై స్పష్టత వస్తుందన్నారు. వర్క్‌స్టేషన్లకు వచ్చి పని చేసుకునేవారికి భవిష్యత్తు అవసరాలకు తగ్గట్టుగా స్కిల్‌ అప్‌గ్రేడేషన్‌ చేయాల్సి ఉందన్నారు. గ్రామాల్లో పరిజ్ఞానం ఉండి సరైన స్కిల్స్‌ లేకపోవడంతో రాణించలేకపోతున్న యువత చాలా మంది ఉన్నారని, వారిలో నైపుణ్యాన్ని పెంచాల్సిన అవసరం ఉందని చంద్రబాబు చెప్పారు.

సీట్ల సామర్థ్యం ప్రకారం ఐటీ రాయితీలు

ఐటీ డెవలపర్లలకు కేటగిరీల వారీగా రాయితీలు ఇస్తామని చంద్రబాబు వెల్లడించారు. డెవలపర్లను మూడు కేటగిరీలుగా విభజించి కోవర్కింగ్‌, నైబర్‌హుడ్‌ వర్కింగ్‌ స్పేస్‌, ఐటీ క్యాంప్‌సలకు వాటి సీట్ల సామర్థ్యం, కార్యాలయ సముదాయం విస్తీర్ణానికి అనుగుణంగా ఆ సబ్సిడీలను ఇస్తామని తెలిపారు. 

కోవర్కింగ్‌ స్పేస్‌కు సబ్సిడీ పొందాలంటే కనీసం 100 సీట్ల సామర్థ్యంకానీ.. పదివేల చదరపు అడుగుల కార్యాలయ సముదాయంకానీ కావాలని చెప్పారు. 

నైబర్‌హుడ్‌ వర్కింగ్‌ స్పేస్‌లకు పది సీట్ల సామర్థ్యం, లేదా వెయ్యి చదరపు అడుగుల కార్యాలయ సముదాయం ఉండాలన్నారు. 

ఐటీ క్యాంప్‌సకు పది లక్షల చదరపు అడుగుల విస్తీర్ణంలో కార్యాలయం ఏర్పాటు చేయాలన్నారు. 

ఏటా రూ. 30 కోట్ల టర్నోవర్‌ లేదా వంద మందికి ఉద్యోగాలు కల్పించే ఐటీ సంస్థలకు ప్రోత్సాహకాలు ఇచ్చేందుకు తుది ప్రణాళికలు సిద్ధం చేయాలని అధికారులను ఆదేశించారు.

Updated Date - Nov 27 , 2024 | 03:48 AM

Sunday, June 2, 2024

Most advanced technologies in the world today

 Most advanced technologies in the world today

Here is a list of some of the most advanced technologies in the world today, including artificial intelligence (AI), along with a brief description of each:


1. Artificial Intelligence (AI)

Description: AI involves creating machines capable of performing tasks that typically require human intelligence. This includes machine learning, natural language processing, computer vision, and robotics.

Applications: Autonomous vehicles, voice assistants (e.g., Siri, Alexa), personalized recommendations, predictive analytics, and healthcare diagnostics.

2. Machine Learning (ML)

Description: A subset of AI that focuses on building systems that learn from data and improve their performance over time without being explicitly programmed.

Applications: Fraud detection, recommendation systems (e.g., Netflix, Amazon), image and speech recognition.

3. Quantum Computing

Description: Uses the principles of quantum mechanics to perform computations much faster than classical computers. Quantum bits (qubits) can represent and process more complex information.

Applications: Cryptography, complex simulations (e.g., drug discovery, materials science), optimization problems.

4. 5G Technology

Description: The fifth generation of mobile network technology offering higher speeds, lower latency, and the ability to connect more devices simultaneously.

Applications: Enhanced mobile broadband, Internet of Things (IoT), autonomous vehicles, remote surgeries.

5. Blockchain Technology

Description: A decentralized ledger technology that ensures secure and transparent record-keeping across distributed networks.

Applications: Cryptocurrencies (e.g., Bitcoin, Ethereum), smart contracts, supply chain management, voting systems.

6. Internet of Things (IoT)

Description: A network of interconnected devices that can collect and exchange data over the internet, enabling smart homes, cities, and industries.

Applications: Smart home devices (e.g., thermostats, lights), industrial automation, health monitoring systems.

7. Edge Computing

Description: Processing data closer to where it is generated rather than in a centralized data center, reducing latency and bandwidth use.

Applications: Real-time analytics, autonomous vehicles, industrial IoT.

8. Augmented Reality (AR) and Virtual Reality (VR)

Description: AR overlays digital information on the real world, while VR immerses users in a fully virtual environment.

Applications: Gaming, training simulations, virtual tours, remote assistance.

9. 3D Printing (Additive Manufacturing)

Description: Creating three-dimensional objects layer by layer using digital models, enabling rapid prototyping and manufacturing.

Applications: Custom prosthetics, aerospace components, automotive parts, construction.

10. CRISPR and Gene Editing

Description: A technology that allows precise modifications to DNA, enabling the correction of genetic defects and the enhancement of biological traits.

Applications: Gene therapy, agriculture (e.g., disease-resistant crops), synthetic biology.

11. Autonomous Vehicles

Description: Vehicles equipped with advanced sensors, AI, and ML to navigate and operate without human intervention.

Applications: Self-driving cars, delivery drones, autonomous public transport.

12. Robotics and Automation

Description: The use of robots to perform tasks with high precision and efficiency, often in environments unsuitable for humans.

Applications: Manufacturing, healthcare (e.g., surgical robots), logistics, exploration (e.g., Mars rovers).

13. Nanotechnology

Description: The manipulation and control of matter at the nanometer scale to create materials and devices with unique properties.

Applications: Medicine (e.g., targeted drug delivery), electronics, materials science.

14. Biotechnology

Description: The use of biological processes and organisms to develop products and technologies for various applications.

Applications: Pharmaceuticals, agricultural biotech (e.g., GMOs), biofuels, bioplastics.

15. Renewable Energy Technologies

Description: Advanced technologies to harness energy from renewable sources like solar, wind, and bioenergy.

Applications: Solar panels, wind turbines, bioenergy plants, energy storage systems (e.g., batteries).

16. Advanced Materials

Description: Development of new materials with exceptional properties for use in various industries.

Applications: Graphene, carbon nanotubes, smart materials, high-temperature superconductors.

17. Cybersecurity Technologies

Description: Advanced methods and tools to protect data and systems from cyber threats.

Applications: Encryption, intrusion detection systems, secure communications, blockchain for security.

18. Wearable Technology

Description: Electronic devices worn on the body that monitor health, fitness, and other personal metrics.

Applications: Smartwatches, fitness trackers, health monitors, augmented reality glasses.

19. Artificial Organs and Bioengineering

Description: Creating synthetic organs and tissues to replace or support biological functions.

Applications: Artificial hearts, bioengineered skin, lab-grown organs.

20. Space Technology

Description: Advanced technologies for exploring and utilizing space.

Applications: Reusable rockets (e.g., SpaceX’s Falcon 9), space tourism, satellite communications, Mars exploration missions.

These technologies are transforming various sectors, driving innovation, and reshaping the future. Each of these advancements brings unique benefits and challenges, influencing how we live, work, and interact with the world.





Thursday, May 16, 2024

Childlessness - Infertility - TEX 13 B

 సంతాన లేమికి కారణం తెలిసింది!

తల్లి శపిస్తే పిల్లలు పుట్టరని చెప్పుకునేవారు. ఇప్పుడు దాన్నే CCMB  Testis-Expressed Protein 13Bతో శాస్త్రీయంగా వివరించింది.


TEX 13 B

childlessness


Childlessness is the state of not having children. Childlessness may have personal, social or political significance.


Childlessness, which may be by choice or circumstance, is distinguished from voluntary childlessness, also called being "childfree", which is voluntarily having no children, and from antinatalism, wherein childlessness is promoted.


Types

See also: Clerical celibacy

Types of childlessness can be classified into several categories:[1]


natural sterility randomly affects individuals. One can think of it as the minimum level of permanent childlessness that we can observe in any given society, and is of the order of 2 percent, in line with data from the Hutterites, a group established as the demographic standard in the 1950s.

social sterility, which one can also call poverty-driven childlessness, or endogenous sterility, describes the situation of poor women whose fecundity has been affected by poor living conditions.

people who are childless by circumstance. These people can be childless because they have not met a partner with whom they would like to have children, or because they tried unsuccessfully to conceive at an advanced maternal age, or because they suffer from certain medical issues, such as endometriosis or polycystic ovary syndrome (PCOS), that make it difficult for them to conceive.

people who are childless by choice.

The first three categories are often grouped under the label "involuntary childlessness". The latter category is often called "voluntary childlessness", also described as being "childfree", occurring when one decides not to reproduce.


TEX13B is important for germ cell development and male fertility

Umesh Kumar, Digumarthi V S Sudhakar, Nithyapriya Kumar, Hanuman T Kale, Rajan Kumar Jha, Nalini J Gupta, B N Chakravarthy, Mamata Deenadayal, Aarti Deenadayal Tolani,  View ORCID ProfileSwasti Raychaudhuri, P Chandra Shekar, Kumarasamy Thangaraj

doi: https://doi.org/10.1101/2022.01.11.475851

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AbstractFull TextInfo/HistoryMetrics Preview PDF

Abstract

The recent epidemiological studies suggest that nearly one out of every 7 reproductive age couples face problem to conceive a child after trying for at least one year. Impaired fertility of the male partner is causative in approximately 50% of the infertile couples. However, the etiologies of large proportion of male infertility are still unclear. Our unpublished exome sequencing data identified several novel genes including TEX13B, which motivated us to further explore the role of TEX13B in male infertility in large infertile case control cohort. Hence in this study, we have examined the role of TEX13B in male infertility by whole gene sequencing 628 infertile and 427 control men and have demonstrated the functional role of Tex13b in spermatogonia GC1spg (GC1) cells. We identified 2 variants on TEX13B which are tightly associated with male infertility. TEX13B gene exclusively expressed in germ cells, but its molecular functions in germ cells are still unknown. Hence, we demonstrated the functional importance of Tex13b in GC1 cell line by genomic manipulation via CRISPR-Cas9 and mass spectrometry-based whole cell proteomics. The gene knock out in GC1 cell line clearly shows that Tex13b play an important role in germ cell growth and morphology. We demonstrate that Tex13b knockout or conditional overexpression in GC1 cells reprograms the metabolic status from an oxidative phosphorylation to glycolysis state and vice versa. In conclusion, our study clearly showed the importance of Tex13b in germ cells development and Its association with male infertility.


Introduction

Infertility, defined as inability of a couple to conceive a child after trying to conceive for one year is a major reproductive health problem in about 15 percent reproductive age couples around the globe (ref). Impaired fertility of the male partner is causative risk factor in approximately 50% of the infertile couples. Data from our laboratory has shown that about 8.5% infertility among Indian men is due to the Y chromosome microdeletion. Further, analysis of several autosomal genes (CAMK4, UBE2B and TNP2-4) accounted for additional 17.5% genetic factors responsible for infertility among Indian men (ref). However, etiologies of large proportion of male infertility are still unclear therefore, it is essential to identify the novel causative mutations for male infertility.


Recent genomic studies revealed that the mutations in mammalian X chromosome have direct impact on fertility because X chromosome is enriched for genes involved in spermatogenesis (Stouffs et al., 2009). A recent study has shown that an x chromosome gene TEX11 mutations were a common cause of meiotic arrest and azoospermia in infertile men (Yang et al., 2015). Another study has stress on the X chromosome genes which express exclusively male germ cells, identified 10 X-linked genes, including Tex13b in mouse as well as human homolog of Tex13, TEX13B. TEX13B is orthologous to mouse gene Tex13b that is found to be is involved in transcriptional regulation during spermatogenesis (Wang et al., 2001). Furthermore, recently it has been shown that Tex13b express specifically pre-leptotene stage of the spermatogonia cells, indicating its potent role in spermatogenesis. The importance of Tex13b in spermatogonia differentiation is indicated in another study since Tex13b found to be most highly connected to the genes specific to germ cells by hub-gene-network analysis (Liao et al., 2017). However, the molecular function TEX13B gene is yet to be explored in germ cells and its association in male infertility.


Since TEX13B has been found as a novel hit in our exome sequencing (unpublished), we have sequenced the coding region (exon 2 and 3) of TEX13B in 628 infertile men (nature of infertile patients) along with 427 ethnically matched fertile controls. We have identified two variants in the coding region of TEX13B and found to be significantly associated with azoospermia patients. To explore the molecular function of TEX13B we created the Tex13b knockout spermatogonia GC1spg (GC1) cells. We specifically choose GC1 cells to characterized Tex13b because these cells belong to pre-leptotene stage of germ cells (spermatogonia B) and Tex13 expresses specifically at this stage (Hofmann, Narisawa, Hess, & Millan, 1992; Wang et al., 2001). Since Tex13b shown to be a transcription factor, hence, to examine the differential protein expression in Tex13b knockout cells we performed isotope labeling by amino acid in cell culture (SILAC) and mass spectrometry-based proteomics. Results in this study clearly show that Tex13b regulate balance between OXPHOS and glycolysis.


Results

TEX13B variants associated with male infertility

TEX13B (Testis-Expressed Protein 13B) is another candidate gene identified by exome sequencing with the non-synonymous variant rs41300872 (p.Gly197Arg) showing significant association with male infertility (OR=1.77, 95% CI); P=0.002. TEX13B is a gene located on X-chromosome and is exclusively expressed in male germ cells and spermatogonia (Wang, McCarrey, Yang, & Page, 2001). To identify additional genetic variants, we sequenced the complete coding region of TEX13B in 628 infertile men (443 NOA, 105 OAT and 80 severe oligozoospermia individuals) along with 427 ethnically matched fertile control men (Table 1). We found an additional rare variant, rs775429506 (p.Gly237Glu) exclusively in two NOA men.



Is infertility genetic in males?

Male-factor infertility and genetics: Is male infertility ...

Some experts estimate that 10–15% of male infertility cases are caused by genetics — others calculate it's more like 60%. So while other male fertility factors like age, diet, lifestyle, and hormones may be common, genetics is sometimes a factor or even the sole cause of male-factor infertility.2 Aug 2022