Dopamine, Serotonin and Rines
Dopamine is a messenger molecule in the brain that allows certain nerve cells to communicate with one another. Underestimated at its discovery, dopamine proved critical to central nervous system functions such as movement, pleasure, attention, mood, and motivation.
Dopamine is broken down into inactive metabolites by a set of enzymes—monoamine oxidase (MAO), catechol-O-methyl transferase (COMT), and aldehyde dehydrogenase (ALDH), acting in sequence.
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5 Best Natural Antidepressants
Ginkgo biloba. If you're looking to take the natural approach to treating mild depression, you may want to give ginkgo biloba supplements a try. ...
5-hydroxytryptophan (5-HTP) This molecule increases levels of the mood-boosting brain chemical serotonin. ...
B vitamins. ...
S-adenosyl-L-methionine (SAMe) ...
Zinc.
Brain serotonin levels can also be raised by eating foods rich in L-tryptophan, such as chicken, eggs, cheese, turkey, beef, salmon and tuna, tempeh, beans, lentils, spinach and other dark green leafy vegetables, pumpkin and chia seeds, and nuts.
Scientists have discovered an enzyme called Rines that regulates MAO-A, a major brain protein controlling emotion and mood. ... Monoamine oxidase A (MAO-A) is an enzyme that breaks down serotonin, norephinephrine and dopamine, neurotransmitters well-known for their influence on emotion and mood.
Brain molecule regulating human emotion, mood uncovered
August 6, 2013
Scientists have discovered an enzyme called Rines that regulates MAO-A, a major brain protein controlling emotion and mood. The enzyme is a potentially promising drug target for treating diseases associated with emotions such as depression.
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A RIKEN research team has discovered an enzyme called Rines that regulates MAO-A, a major brain protein controlling emotion and mood. The enzyme is a potentially promising drug target for treating diseases associated with emotions such as depression.
Monoamine oxidase A (MAO-A) is an enzyme that breaks down serotonin, norephinephrine and dopamine, neurotransmitters well-known for their influence on emotion and mood. Nicknamed the "warrior gene," a variant of the MAOA gene has been associated with increased risk of violent and anti-social behavior.
While evidence points to a link between MAO-A levels and various emotional patterns, however, the mechanism controlling MAO-A levels in the brain has remained unknown.
Now, a research team headed by Jun Aruga at the RIKEN Brain Science Institute has shown for the first time that a ligase named Rines (RING finger-type E3 ubiquitin ligase) regulates these levels. Their research shows that mice without the Rines gene exhibit impaired stress responses and enhanced anxiety, controlled in part through the regulation of MAO-A levels. The study is published today in Journal of Neuroscience.
As the first study to demonstrate regulation of MAO-A protein via the ubiquitin proteasomal system, this research presents a promising new avenue for analyzing the role of MAO-A in brain function. Further research promises insights into the treatment of anxiety, stress-related disorders and impaired social functions.
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Materials provided by RIKEN. Note: Content may be edited for style and length.
Journal Reference:
Kabayama et al. Rines E3 Ubiquitin Ligase Regulates MAO-A Levels and Emotional Responses. Journal of Neuroscience, 2013 DOI: 10.1523/JNEUROSCI.5717-12.2013
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RIKEN. "Brain molecule regulating human emotion, mood uncovered." ScienceDaily. ScienceDaily, 6 August 2013. <www.sciencedaily.com/releases/2013/08/130806203325.htm>.
Dopamine is a messenger molecule in the brain that allows certain nerve cells to communicate with one another. Underestimated at its discovery, dopamine proved critical to central nervous system functions such as movement, pleasure, attention, mood, and motivation.
Dopamine is broken down into inactive metabolites by a set of enzymes—monoamine oxidase (MAO), catechol-O-methyl transferase (COMT), and aldehyde dehydrogenase (ALDH), acting in sequence.
Search Results
Featured snippet from the web
Image result for What is the best natural antidepressant?
Image result for What is the best natural antidepressant?
Image result for What is the best natural antidepressant?
View all
5 Best Natural Antidepressants
Ginkgo biloba. If you're looking to take the natural approach to treating mild depression, you may want to give ginkgo biloba supplements a try. ...
5-hydroxytryptophan (5-HTP) This molecule increases levels of the mood-boosting brain chemical serotonin. ...
B vitamins. ...
S-adenosyl-L-methionine (SAMe) ...
Zinc.
Brain serotonin levels can also be raised by eating foods rich in L-tryptophan, such as chicken, eggs, cheese, turkey, beef, salmon and tuna, tempeh, beans, lentils, spinach and other dark green leafy vegetables, pumpkin and chia seeds, and nuts.
Scientists have discovered an enzyme called Rines that regulates MAO-A, a major brain protein controlling emotion and mood. ... Monoamine oxidase A (MAO-A) is an enzyme that breaks down serotonin, norephinephrine and dopamine, neurotransmitters well-known for their influence on emotion and mood.
Brain molecule regulating human emotion, mood uncovered
August 6, 2013
Scientists have discovered an enzyme called Rines that regulates MAO-A, a major brain protein controlling emotion and mood. The enzyme is a potentially promising drug target for treating diseases associated with emotions such as depression.
Share:
A RIKEN research team has discovered an enzyme called Rines that regulates MAO-A, a major brain protein controlling emotion and mood. The enzyme is a potentially promising drug target for treating diseases associated with emotions such as depression.
Monoamine oxidase A (MAO-A) is an enzyme that breaks down serotonin, norephinephrine and dopamine, neurotransmitters well-known for their influence on emotion and mood. Nicknamed the "warrior gene," a variant of the MAOA gene has been associated with increased risk of violent and anti-social behavior.
While evidence points to a link between MAO-A levels and various emotional patterns, however, the mechanism controlling MAO-A levels in the brain has remained unknown.
Now, a research team headed by Jun Aruga at the RIKEN Brain Science Institute has shown for the first time that a ligase named Rines (RING finger-type E3 ubiquitin ligase) regulates these levels. Their research shows that mice without the Rines gene exhibit impaired stress responses and enhanced anxiety, controlled in part through the regulation of MAO-A levels. The study is published today in Journal of Neuroscience.
As the first study to demonstrate regulation of MAO-A protein via the ubiquitin proteasomal system, this research presents a promising new avenue for analyzing the role of MAO-A in brain function. Further research promises insights into the treatment of anxiety, stress-related disorders and impaired social functions.
Story Source:
Materials provided by RIKEN. Note: Content may be edited for style and length.
Journal Reference:
Kabayama et al. Rines E3 Ubiquitin Ligase Regulates MAO-A Levels and Emotional Responses. Journal of Neuroscience, 2013 DOI: 10.1523/JNEUROSCI.5717-12.2013
Cite This Page:
MLA
APA
Chicago
RIKEN. "Brain molecule regulating human emotion, mood uncovered." ScienceDaily. ScienceDaily, 6 August 2013. <www.sciencedaily.com/releases/2013/08/130806203325.htm>.
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