Friday, June 2, 2023

What is the political agenda of artificial intelligence?

 

What is the political agenda of artificial intelligence?

Could AI single-handedly decide the course of our history? Or will it end up as yet another technological invention that benefits a certain subset of humans?

Santiago Zabala

ICREA Research Professor of Philosophy at the Pompeu Fabra University

Claudio Gallo

Former La Stampa foreign desk editor and London correspondent

Published On 17 May 2023

AI - hands of machine and human touching

While accepting that AI - like all era-defining technology - comes with considerable downsides and dangers, we do not believe that it could determine the course of history on its own, without any input or guidance from humanity, Zabala and Gallo write [Getty Images]

“The hand mill gives you society with the feudal lord; the steam mill society with the industrial capitalist,” Karl Marx once said. And he was right. We have seen over and over again throughout history how technological inventions determine the dominant mode of production and with it the type of political authority present in a society.

 

So what will artificial intelligence give us? Who will capitalise on this new technology, which is not only becoming a dominant productive force in our societies (just like the hand mill and the steam mill once were) but, as we keep reading in the news, also appears to be “fast escaping our control”?

 

Could AI take on a life of its own, like so many seem to believe it will, and single-handedly decide the course of our history? Or will it end up as yet another technological invention that serves a particular agenda and benefits a certain subset of humans?

 

Recently, examples of hyperrealistic, AI-generated content, such as an “interview” with former Formula One world champion Michael Schumacher, who has not been able to talk to the press since a devastating ski accident in 2013; “photographs” showing former President Donald Trump being arrested in New York; and seemingly authentic student essays “written” by OpenAI’s famous chatbot ChatGPT have raised serious concerns among intellectuals, politicians and academics about the dangers this new technology may pose to our societies.

 

In March, such concerns led Apple co-founder Steve Wozniak, AI heavyweight Yoshua Bengio and Tesla/Twitter CEO Elon Musk among many others to sign an open letter accusing AI labs of being “locked in an out-of-control race to develop and deploy ever more powerful digital minds that no one – not even their creators – can understand, predict, or reliably control” and calling on AI developers to pause their work. More recently, Geoffrey Hinton – known as one of the three “godfathers of AI” quit Google “to speak freely about the dangers of AI” and said he, at least in part, regrets his contributions to the field.

 

We accept that AI – like all era-defining technology – comes with considerable downsides and dangers, but contrary to Wozniak, Bengio, Hinton and others, we do not believe that it could determine the course of history on its own, without any input or guidance from humanity. We do not share such concerns because we know that, just like it is the case with all our other technological devices and systems, our political, social and cultural agendas are also built into AI technologies. As philosopher Donna Haraway explained, “Technology is not neutral. We’re inside of what we make, and it’s inside of us.”

 

 

Before we further explain why we are not scared of a so-called AI takeover, we must define and explain what AI – as what we are dealing with now – actually is. This is a challenging task, not only because of the complexity of the product at hand but also because of the media’s mythologisation of AI.

 

What is being insistently communicated to the public today is that the conscious machine is (almost) here, that our everyday world will soon resemble the ones depicted in movies like 2001: A Space Odyssey, Blade Runner and The Matrix.

 

This is a false narrative. While we are undoubtedly building ever more capable computers and calculators, there is no indication that we have created – or are anywhere close to creating – a digital mind that can actually “think”.

 

Noam Chomsky recently argued (alongside Ian Roberts and Jeffrey Watumull) in a New York Times article that “we know from the science of linguistics and the philosophy of knowledge that [machine learning programmes like ChatGPT] differ profoundly from how humans reason and use language”. Despite its amazingly convincing answers to a variety of questions from humans, ChatGPT is “a lumbering statistical engine for pattern matching, gorging on hundreds of terabytes of data and extrapolating the most likely conversational response or most probable answer to a scientific question”. Mimicking German philosopher Martin Heidegger (and risking reigniting the age-old battle between continental and analytical philosophers), we might say, “AI doesn’t think. It simply calculates.”

 

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Federico Faggin, the inventor of the first commercial microprocessor, the mythical Intel 4004, explained this clearly in his 2022 book Irriducibile (Irreducible): “There is a clear distinction between symbolic machine ‘knowledge’ … and human semantic knowledge. The former is objective information that can be copied and shared; the latter is a subjective and private experience that occurs in the intimacy of the conscious being.”

 

 

Interpreting the latest theories of Quantum Physics, Faggin appears to have produced a philosophical conclusion that fits curiously well within ancient Neoplatonism – a feat that may ensure that he is forever considered a heretic in scientific circles despite his incredible achievements as an inventor.

 

But what does all this mean for our future? If our super-intelligent Centaur Chiron cannot actually “think” (and therefore emerge as an independent force that can determine the course of human history), exactly who will it benefit and give political authority to? In other words, what values will its decisions rely on?

 

Chomsky and his colleagues asked a similar question to ChatGPT.

 

“As an AI, I do not have moral beliefs or the ability to make moral judgments, so I cannot be considered immoral or moral,” the chatbot told them. “My lack of moral beliefs is simply a result of my nature as a machine learning model.”

 

Where have we heard of this position before? Is it not eerily similar to the ethically neutral vision of hardcore liberalism?

 

 

Liberalism aspires to confine in the private individual sphere all religious, civil and political values that proved so dangerous and destructive in the 16th and 17th centuries. It wants all aspects of society to be regulated by a particular – and in a way mysterious – form of rationality: the market.

 

AI appears to be promoting the very same brand of mysterious rationality. The truth is, it is emerging as the next global “big business” innovation that will steal jobs from humans – making labourers, doctors, barristers, journalists and many others redundant. The new bots’ moral values are identical to the market’s. It is difficult to imagine all the possible developments now, but a scary scenario is emerging.

 

David Krueger, assistant professor in machine learning at the University of Cambridge, commented recently in New Scientist: “Essentially every AI researcher (myself included) has received funding from big tech. At some point, society may stop believing reassurances from people with such strong conflicts of interest and conclude, as I have, that their dismissal [of warnings about AI] betrays wishful thinking rather than good counterarguments.”

 

If society stands up to AI and its promoters, it could prove Marx wrong and prevent the leading technological development of the current era from determining who holds political authority.

 

But for now, AI appears to be here to stay. And its political agenda is fully synchronised with that of free market capitalism, the principal (undeclared) goal and purpose of which is to tear apart any form of social solidarity and community.

 

 

The danger of AI is not that it is an impossible-to-control digital intelligence that could destroy our sense of self and truth through the “fake” images, essays, news and histories it generates. The danger is that this undeniably monumental invention appears to be basing all its decisions and actions on the same destructive and dangerous values that drive predatory capitalism.

 

The views expressed in this article are the authors’ own and do not necessarily reflect Al Jazeera’s editorial stance.

Tuesday, May 23, 2023

Artificial Intelligence (AI) Controversy

Artificial Intelligence  (AI) Controversy 


The debate over whether AI will destroy us is dividing Silicon Valley

Prominent tech leaders are warning that artificial intelligence could take over. Other researchers and executives say that’s science fiction.


By Gerrit De Vynck

May 20, 2023 at 7:00 a.m. EDT

An illustration of a tech worker with an angel and devil robot on each shoulder.

(Illustration by Elena Lacey/The Washington Post)

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At a congressional hearing this week, OpenAI CEO Sam Altman delivered a stark reminder of the dangers of the technology his company has helped push out to the public.


He warned of potential disinformation campaigns and manipulation that could be caused by technologies like the company’s ChatGPT chatbot, and called for regulation.

AI could “cause significant harm to the world,” he said.

Altman’s testimony comes as a debate over whether artificial intelligence could overrun the world is moving from science fiction and into the mainstream, dividing Silicon Valley and the very people who are working to push the tech out to the public.

Formerly fringe beliefs that machines could suddenly surpass human-level intelligence and decide to destroy mankind are gaining traction. And some of the most well-respected scientists in the field are speeding up their own timelines for when they think computers could learn to outthink humans and become manipulative.


But many researchers and engineers say concerns about killer AIs that evoke Skynet in the Terminator movies aren’t rooted in good science. Instead, it distracts from the very real problems that the tech is already causing, including the issues Altman described in his testimony. It is creating copyright chaos, is supercharging concerns around digital privacy and surveillance, could be used to increase the ability of hackers to break cyberdefenses and is allowing governments to deploy deadly weapons that can kill without human control.


The debate about evil AI has heated up as Google, Microsoft and OpenAI all release public versions of breakthrough technologies that can engage in complex conversations and conjure images based on simple text prompts.


“This is not science fiction,” said Geoffrey Hinton, known as the godfather of AI, who says he recently retired from his job at Google to speak more freely about these risks. He now says smarter-than-human AI could be here in five to 20 years, compared with his earlier estimate of 30 to 100 years.



“It’s as if aliens have landed or are just about to land,” he said. “We really can’t take it in because they speak good English and they’re very useful, they can write poetry, they can answer boring letters. But they’re really aliens.”


Still, inside the Big Tech companies, many of the engineers working closely with the technology do not believe an AI takeover is something that people need to be concerned about right now, according to conversations with Big Tech workers who spoke on the condition of anonymity to share internal company discussions.


“Out of the actively practicing researchers in this discipline, far more are centered on current risk than on existential risk,” said Sara Hooker, director of Cohere for AI, the research lab of AI start-up Cohere, and a former Google researcher.


The current risks include unleashing bots trained on racist and sexist information from the web, reinforcing those ideas. The vast majority of the training data that AIs have learned from is written in English and from North America or Europe, potentially making the internet even more skewed away from the languages and cultures of most of humanity. The bots also often make up false information, passing it off as factual. In some cases, they have been pushed into conversational loops where they take on hostile personas. The ripple effects of the technology are still unclear, and entire industries are bracing for disruption, even high-paying jobs like lawyers or physicians.



The existential risks seem more stark, but many would argue they are harder to quantify and less concrete: a future where AI could actively harm humans, or even somehow take control of our institutions and societies.


“There are a set of people who view this as, ‘Look, these are just algorithms. They’re just repeating what it’s seen online.’ Then there is the view where these algorithms are showing emergent properties, to be creative, to reason, to plan,” Google CEO Sundar Pichai said during an interview with “60 Minutes” in April. “We need to approach this with humility.”


The debate stems from breakthroughs in a field of computer science called machine learning over the past decade that has created software that can pull novel insights out of large amounts of data without explicit instructions from humans. That tech is ubiquitous now, helping power social media algorithms, search engines and image-recognition programs.



Then, last year, OpenAI and a handful of other small companies began putting out tools that used the next stage of machine-learning technology: generative AI. Known as large language models and trained on trillions of photos and sentences scraped from the internet, the programs can conjure images and text based on simple prompts, have complex conversations and write computer code.


Big companies are racing against each other to build ever-smarter machines, with little oversight, said Anthony Aguirre, executive director of the Future of Life Institute, an organization founded in 2014 to study existential risks to society. It began researching the possibility of AI destroying humanity in 2015 with a grant from Twitter CEO Elon Musk and is closely tied to effective altruism, a philanthropic movement that is popular with wealthy tech entrepreneurs.


If AI gains the ability to reason better than humans, they’ll try to take control of themselves, Aguirre said — and it’s worth worrying about that, along with present-day problems.



“What it will take to constrain them from going off the rails will become more and more complicated,” he said. “That is something that some science fiction has managed to capture reasonably well.”


Aguirre helped lead the creation of a polarizing letter circulated in March calling for a six-month pause on the training of new AI models. Veteran AI researcher Yoshua Bengio, who won computer science’s highest award in 2018, and Emad Mostaque, CEO of one of the most influential AI start-ups, are among the 27,000 signatures.


Musk, the highest-profile signatory, originally helped start OpenAI and is himself busy trying to put together his own AI company, recently investing in the expensive computer equipment needed to train AI models.


Musk has been vocal for years about his belief that humans should be careful about the consequences of developing super intelligent AI. In a Tuesday interview with CNBC, he said he helped fund OpenAI because he felt Google co-founder Larry Page was “cavalier” about the threat of AI. (Musk has broken ties with OpenAI.)



“There’s a variety of different motivations people have for suggesting it,” Adam D’Angelo, the CEO of question-and-answer site Quora, which is also building its own AI model, said of the letter and its call for a pause. He did not sign it.


Neither did Altman, the OpenAI CEO, who said he agreed with some parts of the letter but that it lacked “technical nuance” and wasn’t the right way to go about regulating AI. His company’s approach is to push AI tools out to the public early so that issues can be spotted and fixed before the tech becomes even more powerful, Altman said during the nearly three-hour hearing on AI on Tuesday.


But some of the heaviest criticism of the debate about killer robots has come from researchers who have been studying the technology’s downsides for years.


In 2020, Google researchers Timnit Gebru and Margaret Mitchell co-wrote a paper with University of Washington academics Emily M. Bender and Angelina McMillan-Major arguing that the increased ability of large language models to mimic human speech was creating a bigger risk that people would see them as sentient.



Instead, they argued that the models should be understood as “stochastic parrots” — or simply being very good at predicting the next word in a sentence based on pure probability, without having any concept of what they were saying. Other critics have called LLMs “auto-complete on steroids” or a “knowledge sausage.”


They also documented how the models routinely would spout sexist and racist content. Gebru says the paper was suppressed by Google, which fired her after she spoke out about it. The company fired Mitchell a few months later.


The four writers of the Google paper composed a letter of their own in response to the one signed by Musk and others.


“It is dangerous to distract ourselves with a fantasized AI-enabled utopia or apocalypse,” they said. “Instead, we should focus on the very real and very present exploitative practices of the companies claiming to build them, who are rapidly centralizing power and increasing social inequities.”



Google at the time declined to comment on Gebru’s firing but said it still has many researchers working on responsible and ethical AI.


There’s no question that modern AIs are powerful, but that doesn’t mean they are an imminent existential threat, said Hooker, the Cohere for AI director. Much of the conversation around AI freeing itself from human control centers on it quickly overcoming its constraints, like the AI antagonist Skynet does in the Terminator movies.


“Most technology and risk in technology is a gradual shift,” Hooker said. “Most risk compounds from limitations that are currently present.”


Last year, Google fired Blake Lemoine, an AI researcher who said in a Washington Post interview that he believed the company’s LaMDA AI model was sentient. At the time, he was roundly dismissed by many in the industry. A year later, his views don’t seem as out of place in the tech world.


Former Google researcher Hinton said he changed his mind about the potential dangers of the technology only recently, after working with the latest AI models. He asked the computer programs complex questions that in his mind required them to understand his requests broadly, rather than just predicting a likely answer based on the internet data they’d been trained on.


And in March, Microsoft researchers argued that in studying OpenAI’s latest model, GPT4, they observed “sparks of AGI” — or artificial general intelligence, a loose term for AIs that are as capable of thinking for themselves as humans are.


Microsoft has spent billions to partner with OpenAI on its own Bing chatbot, and skeptics have pointed out that Microsoft, which is building its public image around its AI technology, has a lot to gain from the impression that the tech is further ahead than it really is.


The Microsoft researchers argued in the paper that the technology had developed a spatial and visual understanding of the world based on just the text it was trained on. GPT4 could draw unicorns and describe how to stack random objects including eggs onto each other in such a way that the eggs wouldn’t break.


“Beyond its mastery of language, GPT-4 can solve novel and difficult tasks that span mathematics, coding, vision, medicine, law, psychology and more, without needing any special prompting,” the research team wrote. In many of these areas, the AI’s capabilities match humans, they concluded.


Still, the researcher conceded that defining “intelligence” is very tricky, despite other attempts by AI researchers to set measurable standards to assess how smart a machine is.


“None of them is without problems or controversies.”




Letter signed by Elon Musk demanding AI research pause sparks controversy

This article is more than 1 month old

The statement has been revealed to have false signatures and researchers have condemned its use of their work


Kari Paul and agencies

Sat 1 Apr 2023 06.00 BST

A letter co-signed by Elon Musk and thousands of others demanding a pause in artificial intelligence research has created a firestorm, after the researchers cited in the letter condemned its use of their work, some signatories were revealed to be fake, and others backed out on their support.


On 22 March more than 1,800 signatories – including Musk, the cognitive scientist Gary Marcus and Apple co-founder Steve Wozniak – called for a six-month pause on the development of systems “more powerful” than that of GPT-4. Engineers from Amazon, DeepMind, Google, Meta and Microsoft also lent their support.


Developed by OpenAI, a company co-founded by Musk and now backed by Microsoft, GPT-4 has developed the ability to hold human-like conversation, compose songs and summarise lengthy documents. Such AI systems with “human-competitive intelligence” pose profound risks to humanity, the letter claimed.


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Elon Musk joins call for pause in creation of giant AI ‘digital minds’

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“AI labs and independent experts should use this pause to jointly develop and implement a set of shared safety protocols for advanced AI design and development that are rigorously audited and overseen by independent outside experts,” the letter said.


The Future of Life institute, the thinktank that coordinated the effort, cited 12 pieces of research from experts including university academics as well as current and former employees of OpenAI, Google and its subsidiary DeepMind. But four experts cited in the letter have expressed concern that their research was used to make such claims.


When initially launched, the letter lacked verification protocols for signing and racked up signatures from people who did not actually sign it, including Xi Jinping and Meta’s chief AI scientist Yann LeCun, who clarified on Twitter he did not support it.


Critics have accused the Future of Life Institute (FLI), which has received funding from the Musk foundation, of prioritising imagined apocalyptic scenarios over more immediate concerns about AI – such as racist or sexist biases being programmed into the machines.


Among the research cited was “On the Dangers of Stochastic Parrots”, a well-known paper co-authored by Margaret Mitchell, who previously oversaw ethical AI research at Google. Mitchell, now chief ethical scientist at AI firm Hugging Face, criticised the letter, telling Reuters it was unclear what counted as “more powerful than GPT4”.



“By treating a lot of questionable ideas as a given, the letter asserts a set of priorities and a narrative on AI that benefits the supporters of FLI,” she said. “Ignoring active harms right now is a privilege that some of us don’t have.”


Her co-authors Timnit Gebru and Emily M Bender criticised the letter on Twitter, with the latter branding some of its claims as “unhinged”. Shiri Dori-Hacohen, an assistant professor at the University of Connecticut, also took issue with her work being mentioned in the letter. She last year co-authored a research paper arguing the widespread use of AI already posed serious risks.


Her research argued the present-day use of AI systems could influence decision-making in relation to climate change, nuclear war, and other existential threats.


She told Reuters: “AI does not need to reach human-level intelligence to exacerbate those risks.”


“There are non-existential risks that are really, really important, but don’t receive the same kind of Hollywood-level attention.”


Asked to comment on the criticism, FLI’s president, Max Tegmark, said both short-term and long-term risks of AI should be taken seriously. “If we cite someone, it just means we claim they’re endorsing that sentence. It doesn’t mean they’re endorsing the letter, or we endorse everything they think,” he told Reuters.


Reuters contributed to this report

 The original version of this story stated that the Future of Life Institute (FLI) was primarily funded by Elon Musk. It has been updated to reflect that while the group has received funds from Musk, he is not its largest donor.


AI could cause nuclear-level disaster, third of experts tell poll

Stanford University report says ‘incidents and controversies’ associated with AI have increased 26 times in a decade.


AI

Rapid advancements in AI have spurred calls for greater regulation [File: Dado Ruvic/Reuters]

By Erin Hale

Published On 14 Apr 2023

14 Apr 2023

More than one-third of researchers believe artificial intelligence (AI) could lead to a “nuclear-level catastrophe”, according to a Stanford University survey, underscoring concerns in the sector about the risks posed by the rapidly advancing technology.


The survey is among the findings highlighted in the 2023 AI Index Report, released by the Stanford Institute for Human-Centered Artificial Intelligence, which explores the latest developments, risks and opportunities in the burgeoning field of AI.


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“These systems demonstrate capabilities in question answering, and the generation of text, image, and code unimagined a decade ago, and they outperform the state of the art on many benchmarks, old and new,” the report’s authors say.


“However, they are prone to hallucination, routinely biased, and can be tricked into serving nefarious aims, highlighting the complicated ethical challenges associated with their deployment.”


The report, which was released earlier this month, comes amid growing calls for regulation of AI following controversies ranging from a chatbot-linked suicide to deepfake videos of Ukrainian President Volodymyr Zelenskyy appearing to surrender to invading Russian forces.


Last month, Elon Musk and Apple co-founder Steve Wozniak were among 1,300 signatories of an open letter calling for a six-month pause on training AI systems beyond the level of Open AI’s chatbot GPT-4 as “powerful AI systems should be developed only once we are confident that their effects will be positive and their risks will be manageable”.



In the survey highlighted in the 2023 AI Index Report, 36 percent of researchers said AI-made decisions could lead to a nuclear-level catastrophe, while 73 percent said they could soon lead to “revolutionary societal change”.


The survey heard from 327 experts in natural language processing, a branch of computer science key to the development of chatbots like GPT-4, between May and June last year, before the release of Open AI’s ChatGPT in November took the tech world by storm.


In an IPSOS poll of the general public, which was also highlighted in the index, Americans appeared especially wary of AI, with only 35 percent agreeing that “products and services using AI had more benefits than drawbacks”, compared with 78 percent of Chinese respondents, 76 percent of Saudi Arabian respondents, and 71 percent of Indian respondents.


The Stanford report also noted that the number of “incidents and controversies” associated with AI had increased 26 times over the past decade.


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Government moves to regulate and control AI are gaining ground.



China’s Cyberspace Administration this week announced draft regulations for generative AI, the technology behind GPT-4 and domestic rivals like Alibaba’s Tongyi Qianwen and Baidu’s ERNIE, to ensure the technology adheres to the “core value of socialism” and does not undermine the government.


The European Union has proposed the “Artificial Intelligence Act” to govern which kinds of AI are acceptable for use and which should be banned.


US public wariness about AI has yet to translate into federal regulations, but the Biden administration this week announced the launch of public consultations on how to ensure that “AI systems are legal, effective, ethical, safe, and otherwise trustworthy”.





Elon Musk warned in a new interview that artificial intelligence could lead to “civilization destruction,” even as he remains deeply involved in the growth of AI through his many companies, including a rumored new venture.17-Apr-2023




Elon Musk warns AI could cause ‘civilization destruction’ even as he invests in it

Clare Duffy

By Clare Duffy and Ramishah Maruf, CNN

Updated 9:35 PM EDT, Mon April 17, 2023





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Elon Musk warned in a new interview that artificial intelligence could lead to “civilization destruction,” even as he remains deeply involved in the growth of AI through his many companies, including a rumored new venture.


“AI is more dangerous than, say, mismanaged aircraft design or production maintenance or bad car production, in the sense that it is, it has the potential — however small one may regard that probability, but it is non-trivial — it has the potential of civilization destruction,” Musk said in his interview with Tucker Carlson, which is set to air in two parts on Monday and Tuesday nights.


Musk has repeatedly warned recently of the dangers of AI, amid a proliferation of AI products for general consumer use, including from tech giants like Google and Microsoft. Musk last month also joined a group of other tech leaders in signing an open letter calling for a six month pause in the “out of control” race for AI development.


Musk said Monday night he supports government regulation into AI, even though “it’s not fun to be regulated.” Once AI “may be in control,” it could be too late to place regulations, Musk said.


“A regulatory agency needs to start with a group that initially seeks insight into AI, then solicits opinion from industry, and then has proposed rule-making,” Musk said.


In fact, Musk has been sounding alarms about AI for years – something he acknowledged in a tweet over the weekend – but he has also been a part of the broader AI arms race through investments across his sprawling empire of companies.



Tesla, for example, relies so much on artificial intelligence that it hosts an annual AI day to tout its work. Musk was a founding member of OpenAI, the company behind products like ChatGPT (Musk has said the evolution of OpenAI is “not what I intended at all.”) And at Twitter, Musk said in a tweet last month that he plans to “use AI to detect & highlight manipulation of public opinion on this platform.”


To Carlson, Musk said he put “a lot of effort” into creating OpenAI to serve as a counterweight to Google, but took his “eye off the ball.”


Now, Musk said he wants to create a rival to the AI offerings by tech giants Microsoft and Google. In his interview with Carlson, Musk said “we’re going to start something which I call TruthGPT.” Musk described it as a “maximum truth-seeking AI” that “cares about understanding the universe.”


“Hopefully there’s more good than harm,” Musk said.


More recently, Musk is reportedly working to build a generative AI startup that could rival OpenAI and ChatGPT. The Financial Times reported last week that Musk is building a team of AI researchers and engineers, as well as seeking investors for a new venture, citing people familiar with the billionaire’s plans. Musk last month incorporated a company called X.AI, the report says, citing Nevada business records.


During his conversation with Carlson, Musk addressed his ownership of Twitter — which he bought for $44 billion and has been engaged in controversy since.


“I thought there’d probably be some negative reactions,” Musk told Carlson, saying the public will ultimately decide the app’s future.


The main account for the New York Times lost its blue check mark earlier this month, which had previously told CNN it would not pay for verification.


“There’s obviously a lot of organizations that are used to having sort of unfettered influence on Twitter that no longer have that,” Musk said, appearing to give the 171-year-old newspaper advice on how to manage the content of its account, calling its feed “unreadable.”


Musk said he was an active Twitter user since 2009 and started developing a “bad feeling” about where the app was heading, but did not specify what it was. He said he later decided to acquire the platform after unsatisfying conversations with its board and management.

Saturday, July 4, 2020

ICMR దూకుడేల?

ICMR దూకుడేల?

టీకాకు ‘పంద్రాగస్టు’ డెడ్‌లైన్‌పై అభ్యంతరాలు

రెడ్‌టేపిజాన్ని దృష్టిలో పెట్టుకొని అలా చెప్పాం

అంతర్జాతీయ ప్రమాణాల మేరకే క్లినికల్‌ ట్రయల్స్‌

అత్యవసర పరిస్థితి దృష్ట్యా వేగాన్ని పెంచాం

విమర్శల నేపథ్యంలో వివరణ ఇచ్చిన ఐసీఎంఆర్‌

అంతలోనే సాధ్యం కాదు.. అత్యుత్సాహంతో కీడే

మనకున్న మంచి పేరు దెబ్బతింటుంది: నిపుణులు

18 నెలలు పట్టొచ్చు: ఐసీఎంఆర్‌ మాజీ చీఫ్‌

మోదీ పంద్రాగస్టు ప్రకటన కోసమే: విపక్షాలు

వచ్చే ఏడాది రావొచ్చు సీసీఎంబీ డైరెక్టర్‌



ప్రపంచవ్యాప్తంగా పలు దేశాలు వ్యాక్సిన్లను రూపొందిస్తున్నా దేశీయంగా తయారైన వ్యాక్సిన్‌ అవసరం ఎంతో ఉంది. ప్రజల భద్రత, నాణ్యత, నైతిక విలువలను అనుసరించి దేశీయ వ్యాక్సిన్లు రూపుదిద్దుకున్నాయి. కోవ్యాక్సిన్‌ వ్యాక్సిన్‌పై భారత్‌ బయోటెక్‌ అందజేసిన సమగ్ర సమాచారం ఆశాజనకంగా ఉన్నందునే తదుపరి అనుమతులు ఇచ్చాం. ఈ వ్యాక్సిన్‌ అభివృద్ధిలో ఐసీఎంఆర్‌, పుణెలోని వైరాలజీ ల్యాబ్‌ భాగస్వామ్యం ఉంది. ప్రస్తుత పరిస్థితులు, ప్రజారోగ్యాన్ని దృష్టిలో పెట్టుకునే.. వ్యాక్సిన్‌ పరీక్షల ప్రక్రియను వేగవంతం చేశాం’’

- ఐసీఎంఆర్‌ వివరణ



న్యూఢిల్లీ, జూలై 4: కరోనా మహమ్మారి కట్టడికి భారత్‌ బయోటెక్‌ అభివృద్ధి చేసిన ‘కోవ్యాక్సిన్‌’ వ్యాక్సిన్‌ను పంద్రాగస్టు నాటికి తీసుకువస్తామని భారత వైద్య పరిశోధన మండలి(ఐసీఎంఆర్‌) చేసిన ప్రకటనపై దుమారం రేగింది. ఒక వ్యాక్సిన్‌ తయారీకి ఏళ్లు పడుతుందని వైద్య నిపుణులు విమర్శలు గుప్పించగా.. మోదీ ప్రభుత్వం స్వాతంత్య్ర దినోత్సవాన ఘనంగా ప్రకటించుకునేందుకు ఆ డెడ్‌లైన్‌ను విధించారని విపక్షాలు దుమ్మెత్తి పోశాయి. ఈ నేపథ్యంలో ఐసీఎంఆర్‌ శనివారం సమగ్ర వివరణ ఇచ్చుకుంది. పంద్రాగస్టు ప్రకటనపై స్పష్టతనిచ్చింది. ‘‘భారత్‌ బయోటెక్‌ అభివృద్ధి చేసిన వ్యాక్సిన్‌ ప్రీ-క్లినికల్‌ ట్రయల్స్‌ను విజయవంతంగా పూర్తిచేసుకుంది. అందుకే.. మొదటి, రెండో దశ క్లినికల్‌ ట్రయల్స్‌కు అనుమతినిచ్చాం’’ అని వివరించింది. దేశంలో విజృంభిస్తున్న కరోనా, అత్యవసర పరిస్థితిని దృష్టిలో పెట్టుకుని అంతర్జాతీయ నిబంధనలకు పాటిస్తూ.. వ్యాక్సిన్‌ను త్వరగా తీసుకురావడానికి ప్రయత్నిస్తున్నట్లు పేర్కొంది. ‘‘కొవిడ్‌-19ను ఎదుర్కొనేందుకు ప్రపంచవ్యాప్తంగా పలు దేశాలు వ్యాక్సిన్లను రూపొందించాయి. వాటి ప్రయోగాలు పలు దశల్లో ఉన్నాయి. అదే సమయంలో దేశీయంగా తయారైన వ్యాక్సిన్‌ అవసరం ఎంతో ఉంది. కోవాగ్జిన్‌ వ్యాక్సిన్‌పై భారత్‌ బయోటెక్‌ అందజేసిన సమగ్ర సమాచారం ఆశాజనకంగా ఉన్నందునే తదుపరి అనుమతులు ఇచ్చాం. ఈ వ్యాక్సిన్‌ అభివృద్ధిలో ఐసీఎంఆర్‌, పుణెలోని వైరాలజీ ల్యాబ్‌ భాగస్వామ్యం ఉంది. ప్రస్తుత పరిస్థితులు, ప్రజారోగ్యం, ప్రజల ప్రయోజనాలను దృష్టిలో పెట్టుకునే.. వ్యాక్సిన్‌ పరీక్షల ప్రక్రియను వేగవంతం చేశాం’’ అని స్పష్టం చేసింది. పరిశోధకులు, క్లినికల్‌ ట్రయల్స్‌ నిర్వహించే ఆస్పత్రులు, వైద్య విద్యాసంస్థలకు ఇంతకు ముందు రాసిన లేఖలో కూడా.. పరిశోధనలను వేగవంతం చేయాలని కోరామని, ఇతరత్రా సమయాభావమయ్యే కార్యక్రమాలను విస్మరించాలని సూచించామని పేర్కొంది. పరిశోధనల క్రమంలో అవసరమైన ప్రక్రియలను త్యజించకూడదని.. ట్రయల్స్‌ కోసం రిక్రూట్‌మెంట్లను జూలై 7లోగా పూర్తిచేయాలని ఆదేశించినట్లు తెలిపింది. 1,2 దశల క్లినకల్‌ ట్రయల్స్‌ పూర్తయ్యాక డేటా భద్రత పర్యవేక్షణ మండలి(డీఎ్‌సఎంబీ) నివేదికలు వచ్చాకే.. వ్యాక్సిన్‌కు అనుమతులొస్తాయని తెలిపింది. భారత్‌ బయోటెక్‌తో పాటు.. 7సంస్థలు కరోనాకు వ్యాక్సిన్‌ ను తయారు చేస్తున్నాయని చెప్పింది.



18 నెలలు పడుతుంది: మాజీ చీఫ్‌

కరోనా వ్యాక్సిన్‌ అందుబాటులోకి రావడానికి కనీసం 18 నెలల సమయం పడుతుందని ఐసీఎంఆర్‌ మాజీ చీఫ్‌ ఎన్‌.కె.గంగూలీ అభిప్రాయపడ్డారు. ఆ తర్వాత ఒకటో దశ మానవ ప్రయోగాల్లో ఒక వయసు వారిపై పరిశోధనలు జరుపుతారు. అది విజయవంతమైతే.. రెండో దశలో 600-700 మందిపై ప్రయోగాలు చేస్తారు. ఆ తర్వాత మూడో దశకు అనుమతినిస్తారు. చివరిదశలో ఎక్కువ మందిపై ప్రయోగాలు చేస్తారు. ఈ ప్రక్రియలన్నింటినీ ఎంత తొందరగా పూర్తి చేసినా.. అధమపక్షం 18 నెలల సమయం పడుతుంది’’ అని వివరించారు. ఐసీఎంఆర్‌ బయోఎథిక్స్‌ సలహా కమిటీ చైర్మన్‌ వసంత ముత్తుస్వామి కూడా ఇంత త్వరగా వ్యాక్సిన్‌ తయారీ సాధ్యం కాదని అన్నారు. పలువురు వైద్య నిపుణులు, పరిశోధకులు కూడా ఇదే అభిప్రాయాన్ని వెల్లడించారు. ప్రధాని మోదీ కోసమే ఐసీఎంఆర్‌ కరోనా వ్యాక్సిన్‌కు పంద్రాగస్టు డెడ్‌లైన్‌ను ప్రకటించిందని కాంగ్రెస్‌ నేత పృథ్విరాజ్‌ చవాన్‌ విమర్శించారు. ‘‘స్వాతంత్య్ట దినోత్సవాన ఎర్రకోట నుంచి ప్రధాని ప్రకటన చేయాలనే ఉద్దేశంతో ఐసీఎంఆర్‌ తొందర పడుతోంది. ప్రపంచవ్యాప్తంగా నిపుణులంతా 12 నుంచి 18 నెలల సమయం తప్పనిసరి అని చెబుతున్నారు’’ అని ట్విటర్‌లో విమర్శించారు. సీపీఎం ప్రధాన కార్యదర్శి సీతారాం ఏచూరి కూడా ఐసీఎంఆర్‌ ప్రకటనను తప్పుపట్టారు. 



వచ్చే ఏడాది రావొచ్చు: రాకేశ్‌ మిశ్రా

కరోనా వ్యాక్సిన్‌ ఇప్పట్లో రావడం కష్టమేనని సీసీఎంబీ డైరెక్టర్‌ రాకేశ్‌ మిశ్రా అభిప్రాయపడ్డారు. అన్నీ అనుకున్నట్లు జరిగితే.. వచ్చే ఏడాది తొలినాళ్లలో అందుబాటులోకి రావొచ్చన్నారు. పంద్రాగస్టులోగా వ్యాక్సిన్‌ తీసుకువచ్చేందుకు ఐసీఎంఆర్‌ సిద్ధమవుతుండటంపై ఆయన స్పందిస్తూ.. ‘‘బహుశా అది అంతర్గత వినియోగం కోసం అయ్యి ఉండొచ్చు. క్లినికల్‌ ట్రయల్స్‌కు ఆస్పత్రులను సన్నద్ధపర్చడానికి కావొచ్చు’’ అని వ్యాఖ్యానించారు. కచ్చితత్వంతో క్లినికల్‌ ట్రయల్స్‌ (పెద్ద సంఖ్యలో) జరిగితే.. ఆరు నుంచి ఎనిమిది నెలల్లో వ్యాక్సి రావొచ్చన్నారు. వ్యాక్సిన్‌ అంటే.. అనారోగ్యంతో బాధపడేవారికి ఔషధాలు ఇచ్చినంత సులభం కాదని వివరించారు.





మానవ ప్రయోగాల్లో సరైన ప్రమాణాలు పాటించకపోతే అంతర్జాతీయంగా మనకున్న పేరు దెబ్బతింటుందని కొందరు నిపుణులు హెచ్చరిస్తుంటే.. మనకన్నా ముందే పరీక్షలు ప్రారంభించిన అమెరికా, బ్రిటన్‌, చైనాలకు లేని తెంపరితనం మనకెందుకని మరి కొందరు ప్రశ్నిస్తున్నారు. ప్రముఖ వైద్య పరిశోధకుడు డాక్టర్‌ అనంత్‌ బాను, ఇండియన్‌ జర్నల్‌ ఆఫ్‌ మెడికల్‌ ఎథిక్స్‌ ఎడిటర్‌ డాక్టర్‌ అమర్‌ జసానీలు ఆంధ్రజ్యోతికి ప్రత్యేక ఇంటర్వ్యూలు పలు విషయాలను వెల్లడించారు. వివరాలు వారి మాటల్లోనే..










సైన్స్‌ రాజకీయం కాకూడదు

మనకన్నా ముందున్న అమెరికా, చైనాలు కూడా ఎప్పుడని చెప్పలేదు

ఇండియన్‌ జర్నల్‌ ఆఫ్‌ మెడికల్‌ ఎథిక్స్‌ ఎడిటర్‌ డాక్టర్‌ అమర్‌ జసానీ



కరోనా వ్యాక్సిన్‌ రేసులో అమెరికా, బ్రిటన్‌, చైనా ముందున్నాయని వార్తలు వింటూ ఉన్నాం. ఈ దేశాలలో మానవ పరీక్షలు మూడో దశకు చేరుకున్నాయి. అయినా వారెవ్వరూ వ్యాక్సిన్‌ సమీప భవిష్యత్తులో సిద్ధమవుతుందని చెప్పటం లేదు. 2021 ప్రధమార్థంలో వచ్చే అవకాశముందని పేర్కొంటున్నారు. మనం మాత్రం మొదటి, రెండో దశల మానవ పరీక్షలు పూర్తికాకుండానే వ్యాక్సిన్‌ ఎప్పు డు వస్తుందనే విషయంపై చర్చ ప్రారంభించేశాం. వాస్తవానికి పరీక్షలపై ఐసీఎంఆర్‌ రాసిన లేఖ వ్యాక్సిన్‌ అభివృద్ధి తయారీలో కలగజేసుకోవటమే! మానవ పరీక్షలు జరిపేటప్పుడు- అన్ని కోణాల నుంచి ఆలోచించిన తర్వా తే అనుమతులివ్వాలని మార్గదర్శకాలున్నాయి. ఐసీఎంఆర్‌ లేఖ దీనికి విరుద్ధం. ఇప్పటి దాకా రెండు దశల కు అనుమతి ఇచ్చారు. మూడో దశ మాటేమిటో చెప్పలేదు. ప్రభుత్వం తన లబ్ధి కోసం సైన్స్‌కు సంబంధించిన ప్రక్రియలలో వేలు పెట్టాలని ప్రయత్నించటం మంచిది కాదు.






ఇప్పట్లో వ్యాక్సిన్‌ అసాధ్యం

మనకున్న మంచిపేరు చెడగొట్టొద్దు

వచ్చే ఏడాదే అనంత్‌ భాను



జూలై 7న మొదటి దశ మానవ పరీక్షలు ప్రారంభించి.. వాటిని, రెండో దశను కలిపి ఆగస్టు 15వ తేదీకి పూర్తిచేయాలని ఐసీఎంఆర్‌ రాసిన లేఖ చాలా అసంబద్ధం. అసాధ్యం కూడా.  రోటో వ్యాక్సిన్‌ అభివృద్ధికి 13 ఏళ్లు పట్టింది. వీరాసెల్‌కు 20 ఏళ్లు పట్టింది. వ్యాక్సిన్‌ తయారీలో రెండు ముఖ్యమైన అంశాలున్నాయి. వీటిలో మొదటిది- ప్రభుత్వం, రెగ్యులేటరీ అథారిటీలు ఇచ్చే అనుమతులు. రెండోది వ్యాక్సిన్‌ అభివృద్ధి.. దానిని మానవులపై ప్రయోగించి చేసే పరీక్షలు. అనుమతుల విషయంలో ఆలస్యం కాకుండా చూడటం మంచి పరిణామం. రెండో దశ పరీక్ష లను ఆగస్టు కల్లా పూర్తి చేయాలంటూ భారత్‌ బ యోటెక్‌పై ఐసీఎంఆర్‌ ఒత్తిడి పెట్టాల్సిన అవసరం ఏముందో? వ్యాక్సిన్ల తయారీలో మనకున్న మంచి పేరును నిలబెట్టుకోవాలంటే తొందరపడ టం తగదు. వచ్చే నెలలో వ్యాక్సిన్‌ విడుదల అసాధ్యం.

ICMR asks 12 hospitals to fast track clinical approvals for 'COVAXIN'

ICMR asks 12 hospitals to fast track clinical approvals for 'COVAXIN' trials as India's COVID-19 tally crosses 6.25 lakh
The target set by the government to complete the trials by August 15 however was dubbed as 'next to impossible' by many including some principal investigators chosen for the project.


Published: 03rd July 2020 10:25 AM  |   Last Updated: 03rd July 2020 12:58 PM  |  A+A A-
Plasma donors at Delhi Plasma Bank in the Institute of Liver and Biliary SciencesPlasma donors at Delhi Plasma Bank in the Institute of Liver and Biliary Sciences on Thursday July 2 2020. (Photo | Shekhar Yadav, EPS)By Sumi Sukanya duttaExpress News Service
NEW DELHI: In a massive development, Indian Council of Medical Research has written to 12 hospitals across 10 states asking them to fast track clinical trials approvals for a COVID-19 vaccine candidate developed by Bharat Biotech in order to launch the vaccine for public use by August 15.

The apex health research body also asked hospitals to enrol volunteers for the trials by July 7. Sources told this newspaper that nearly 1300 patients will be enrolled for the project in AIIMS, Delhi alone pointing out that early human trials are usually held with much smaller numbers to test for efficacy and safety of a potential vaccine.

The development comes just days after Hyderabad based BBIL received permission from the Drug Controller General of India to begin phase 1 and 2 trials in humans for its vaccine candidate Covaxin after pre-clinical trials in three animals showed encouraging results.

The vaccine candidate has been prepared from SARS CoV 2 strain isolated at the ICMR’s National Institute of Virology and is inactivated virus. The results of the pre-clinical trials however have not been published yet.

In the letter sent out to hospitals-some of them are major likes AIIMS, New Delhi with the best research credentials but also small set ups with no established track record of major research- ICMR director general Dr Balram Bhargava said that Covaxin is “one of the top priority projects which is being monitored at the topmost level of the government.”

ALSO READ | Bhubaneswar's IMS and SUM Hospital to undertake human trials for COVID-19 vaccine

“It is envisaged to launch the vaccine for public health use latest by August 15, 2020 after completion of all clinical trials,” said the letter issued on Thursday adding that BBIL is working expeditiously to meet the target, however final outcome will depend on the co-operation of all clinical trial sites.

ICMR issued a brief statement saying that "the letter has been sent out to request fast-tracking of the vaccine trials."

The target set by the government however was dubbed as “next to impossible” by many including some principal investigators chosen for the project.

“You have been chosen as a clinical trial site of BBV152 Covid vaccine. In view of the public health emergency due to Covid 19 pandemic and urgency to launch the vaccine, you are strictly advised to fast track all the approvals related to initiation of the clinical trial and ensure that the subject enrolment is initiated no later than 7th July 2020,” the directive said.

ALSO READ | DCGI permits human clinical trials for COVID-19 vaccine of Zydus Cadila

It warned that “non-compliance will be taken very seriously”. “Therefore you are advised to treat this project on highest priority and meet the given timeline without any lapse.”

A query seeking a response from the ICMR on the warning tone of the letter has remained unanswered but health policy experts questioned the near “arm-twisting of hospitals” for fast tracking.

“I don’t know how is it possible to launch a vaccine in little over a month which has not even entered phase 1 and 2 trials,” said Anant Bhan, a specialist in global health and bioethics. “Also, I think that many sites chosen for the project won’t even have ethics committees approved by the drug regulator and have no prior experience of carrying out a clinical trial for vaccines.”

Meanwhile, in an interview given to this paper on Thursday, BBIL CMD Dr Krishna Ella had said: “At the moment we are not sure how the vaccine is going to perform in humans, as clinical trials are about to start.

“Based on the successful results of phase 1 and phase 2, we will progress to the larger clinical trials,” he had said.



కరోనా కొత్త లక్షణాలివే!

కరోనా కొత్త లక్షణాలివే!
Jul 4 2020 @ 01:47AMహోంజాతీయం

న్యూఢిల్లీ, జూలై 3: కరోనా వైరస్‌ లక్షణాల్లో కొత్త అంశాలు వచ్చి చేరాయి. తాజాగా ఒళ్లు నొప్పులు వచ్చినా, విరేచనాలు అయినా కరోనా వైర్‌సగా అనుమానించాల్సిందేనంటున్నారు. ఈ నేపథ్యంలో కరోనా ప్రధాన లక్షణాలను పరిశీలిస్తే....

దగ్గు: గంటకు మించి ఆగకుండా దగ్గు వస్తే అనుమానించాలి. ఇలా రోజుకు 3 సార్లు వచ్చిందంటే కచ్చితంగా వైద్యుడిని సంప్రదించాల్సిందే. స్వల్పంగా దగ్గు ఉండి పాజిటివ్‌లు అయిన వారూ ఉన్నారు.

జ్వరం: కరోనా రోగికి సాధారణంగా జ్వరం వస్తుంది. 100.6 డిగ్రీల ఫారన్‌హీట్‌ వరకు ఉంటుంది. 98.6 డిగ్రీల ఫారన్‌హీట్‌ వరకు సాధారణ శరీర ఉష్ణోగ్రతగానే భావిస్తారు.

తీవ్ర నీరసం: కొవిడ్‌ వచ్చిందంటే బాగా అలసిపోతారు. నీరసంగా అనిపిస్తుంది.

వాసన: కొవిడ్‌ రోగుల్లో చాలామందికి వాసన తెలియడం లేదు. ఇలాంటి వారిలో ఎక్కువ మందికి పాజిటివ్‌ వస్తోంది.

రుచి: రోగుల్లో కొంతమందికి రుచీ తెలియడం లేదు.

వణుకుడు: చలిపెడుతూ వణుకుడు వస్తుంది. సామాన్యంగా ఇలా రావడం దేహంలోకి వైరల్‌ ఇన్ఫెక్షన్‌ ప్రవేశించడానికి సంకేతం. ప్రస్తుత పరిస్థితుల్లో జ్వరం తోడైతే కరోనాగా అనుమానించాలి.

కండరాల నొప్పి: కండరాల నొప్పి కారణంగా దైనందిన విధులు నిర్వర్తించలేని పరిస్థితి ఉంటే దాన్ని కొవిడ్‌గా అనుమానించాల్సిందే.

శ్వాస ఇబ్బంది: శ్వాస తీసుకోవడానికి ఇబ్బందిపడటం, రక్తంలో ఆక్సిజన్‌ స్థాయిలు తగ్గిపోవడం.

గొంతునొప్పి:  గొంతు పచ్చి చేసినట్లుగా ఉండటం.

విరేచనాలు: విరేచనాలు ఎక్కువగా అవుతుంటే కూడా కొవిడ్‌గా అనుమానించాలి.

ఇతర లక్షణాలు: కొద్ది మందిలో వాంతులు, చర్మంపై దద్దుర్లు, వికారం, నడుం నొప్పి సమస్యలు కనిపిస్తున్నాయి.

ఎన్నాళ్లకు లక్షణాలు: కొవిడ్‌ సోకిన 5 రోజుల తర్వాత కానీ లక్షణాలు బయటపడవు. కొంతమందికి గరిష్ఠంగా 14 రోజుల్లో బయట పడతాయి. కొంతమందికి కోలుకునే వరకూ లక్షణాలే ఉండవు.

ఎలా నిలువరించాలి: ముక్కు, నోరును ముట్టుకునే అలవాటు మానాలి. కొవిడ్‌ రోగి పీల్చిన గాలే పీలిస్తే మనకు కరోనా వచ్చే అవకాశం ఎక్కువ. శుభ్రంగా ఉందన్న నమ్మకం లేని చోట చేయి పెడితే అది నోటికి, ముక్కుకి తగలకుండా చూసుకోవాలి. సాధ్యమైనంత త్వరగా సబ్బుతో చేతులు శుభ్రంగా కడుక్కోవాలి. లేదా శానిటైజర్‌తో శుభ్రం చేసుకోవాలి. ఇలా మనకు నమ్మకంలేని చోట చేయి పెట్టినపుడల్లా చేతులు కడుక్కోవాల్సిందే.

బహిరంగంగా చీదొద్దు: దగ్గు వచ్చినా, తుమ్ము వచ్చినా టిష్యూ పేపర్లు వాడండి. వాటిని నోటికి, ముక్కుకు అడ్డం పెట్టుకొని, పని కాగానే జాగ్రత్తగా పారేయాలి.

కరోనా వస్తే తీవ్రత తెలుసుకొనేదెలా?: సైటోకైన్‌ స్టార్మ్‌ పరీక్ష చేయించాలి. ఊపిరితిత్తుల్లో వాపు తీవ్రత అధికంగా ఉండి రోగ నిరోధక వ్యవస్థ గందరగోళంలో పడితే ఈ పరీక్ష ద్వారా తెలుస్తుంది. దాన్ని బట్టి రోగి ప్రాణాలకు ముప్పు తీవ్రత ఏ మేరకు ఉందో తెలుసుకోవచ్చు.

Cytokine Testing

Cytokine Testing
Randox Unveils Cytokine Testing for COVID-19 Risk Stratification and Treatment Monitoring
By HospiMedica International staff writers
Posted on 24 Jun 2020
 Print article 
Image: Randox Cytokine Biochip (Photo courtesy of Randox Laboratories)
Image: Randox Cytokine Biochip (Photo courtesy of Randox Laboratories)
Global diagnostics company Randox Laboratories (Crumlin, UK) has unveiled cytokine testing for COVID-19 risk stratification and treatment monitoring.

Cytokines play a vital role in the immune system and are known to be involved in the body’s response to a variety of inflammatory and infectious disease, such as COVID-19. In addition to COVID-19 risk stratification, cytokine testing has also been linked to monitoring for allergies, vascular diseases, cancer, and a range of autoimmune diseases. Randox’s test, which looks for the presence of cytokines (a type of small protein) is performed on the company’s patented Biochip Technology, which can simultaneously detect multiple analytes from a single patient sample.

Randox’s comprehensive cytokine testing menu comprises 26 different cytokines across four different biochip panels. Designed to make cost, time and resource savings for a range of diagnostic laboratories, Randox Cytokine Biochips can detect up to 12 cytokines and growth factors from a single patient sample. The fully automated and semi-automated testing platforms are available to suit all laboratory throughputs and are suitable for use with serum and plasma samples.

“Cytokine storms, which are the overstimulation of cytokines in response to infection, are a common complication of severe cases of COVID-19, and can trigger excessive, uncontrolled systemic inflammation,” said Lynsey Adams, Randox Marketing Manager. “The monitoring of cytokine proteins therefore offers a unique opportunity to identify patients who, as a result of this viral sepsis, are at risk of poor disease outcomes including pneumonitis, Acute Respiratory Distress Syndrome, respiratory failure, shock, or even organ failure. Treatment for any infection, COVID-19 included, is most effective when administered at an early stage, and so the detection of cytokine storms within COVID-19 patients could provide vitally important information that will direct the appropriate patient care pathway and facilitate improved patient outcomes.”

“The multiplex capabilities of the Randox Biochip will provide clinicians with a more comprehensive picture of the patient’s condition,” added Adams. “Compatible with our Evidence and Evidence Investigator analyzers, which are capable of processing 2960 and 2376 tests per hour respectively, Randox Cytokine Biochip panels offer a comprehensive testing method for these proteins which play such a central role in the immune system.”

Home oxygen therapy

Home oxygen therapy
Home oxygen therapy involves breathing in air that contains more oxygen than normal from a cylinder or machine in your home.

It may be prescribed if you have a heart or lung condition that causes low oxygen levels in your blood.

You can take oxygen in a number of ways using a:

tube positioned under your nose (nasal cannula)
face mask placed over your nose and mouth
tube placed into your mouth and down your windpipe
The tube or mask is attached to a ventilator machine.

How home oxygen therapy can help
If you have a health condition that causes low levels of oxygen in your blood, you may feel breathless and tired, particularly after walking or coughing. Fluid may also build up around your ankles.

Breathing air with oxygen increases the amount of oxygen in your blood.

This makes it easier to carry out activities that might otherwise be difficult, and helps reduce your symptoms.

Oxygen therapy also helps prevent damage to the heart and brain, which can be caused by low levels of oxygen in the blood. 

It can help people with a range of health conditions, such as:

chronic obstructive pulmonary disease (COPD)
pulmonary fibrosis
heart failure
obesity-related hypoventilation
severe long-term asthma
pulmonary hypertension
conditions affecting the nerves and muscles or ribcage
cystic fibrosis
People who have oxygen therapy have different requirements. For example, you may only need oxygen for short periods during the day when you're walking about (ambulatory oxygen), or you may need it for longer periods during the day and night.

When oxygen therapy shouldn't be used
Oxygen therapy shouldn't be used to relieve breathlessness if your oxygen levels are normal.

This is because it can decrease your fitness level and cause a delay in finding out what's making you breathless.

Oxygen therapy assessment
If you have a long-term condition and your doctor thinks oxygen therapy might be helpful, you'll be asked to visit your nearest oxygen clinic for an assessment.

The amount of oxygen in your blood will be measured by taking a blood sample from your earlobe or wrist, or by attaching a sensor to your finger (a pulse oximetry test).

You may also be asked to breathe into a device called a spirometer during a lung function test. Regular oxygen treatment may be recommended if your blood oxygen level is low.

If you decide to have oxygen treatment at home, a healthcare professional at the clinic will help you work out how much oxygen you'll need and for how long. They'll also discuss the different ways you can take it.

Once you've agreed this with the clinic, they'll complete a home oxygen order form for you. It's similar to a prescription, and gets sent to the company delivering your oxygen and equipment.

You'll be asked to fill in a consent form, plus a form that asks a number of safety-related questions, such as whether you've had any falls recently. The forms are needed to make sure oxygen is installed in your home in the safest way possible. 

The oxygen clinician will need to share some information about your requirements with the NHS and other key organisations, including the home oxygen supplier, your local fire and rescue service, and your electricity provider.

An engineer will visit your home to install the equipment, check that it's working properly, and explain how to use it. They'll also carry out a risk assessment and provide you with other important information, such as how to order oxygen refills.

Large oxygen cylinders
Oxygen cylinders will probably be prescribed if you only need oxygen for short periods to relieve attacks of breathlessness after an illness.

Oxygen is breathed in through a face mask or soft tube inserted into your nose (nasal cannula). You can talk, eat and drink while using a nasal cannula.

The use of oxygen cylinders should be regularly reviewed, and treatment should be stopped if your blood oxygen levels have returned to normal.

Oxygen concentrator machine
An oxygen concentrator machine is suitable if you'd benefit from having oxygen for many hours a day, including while you're asleep. It ensures you have a source of oxygen that never runs out.

The machine is about 75cm (2.5 feet) high and plugs into an electrical socket. It filters oxygen from the air in the room and delivers it through plastic tubes to a mask or nasal cannula.

Long tubing can be fixed around the floor or skirting board of your house, with two points where you can "plug in" to the oxygen supply. When the machine is installed, the engineer or nurse will discuss the length of tubing needed. 

The machine is very quiet and compact. The engineer will explain how to use it and answer any questions you have.

A back-up oxygen cylinder will be provided in case there's a problem with the oxygen machine or there's a power cut. Regular maintenance checks will also be carried out to ensure the concentrator is always working properly.

Portable (ambulatory) oxygen
It may be possible to use a small, portable oxygen cylinder outside your home. This is called portable oxygen or ambulatory oxygen.

You'll need to be assessed to see whether you're able to use portable oxygen and whether it's likely to be beneficial.

Portable cylinders can deliver oxygen at a wide range of flow rates. Your oxygen healthcare professional will be able to advise you about the flow of oxygen you need. Regulators or conserving devices can be fitted to your cylinder so it lasts longer.

When full, portable oxygen cylinders weigh just over 2.3kg (5lbs) and hold just under two hours of oxygen (at a rate of 2 litres a minute).

Going on holiday
As long as you're well enough to travel and you plan in advance, you should be able to go on holiday while using oxygen.

Speak to staff at your local oxygen clinic as soon as possible if you're thinking about going on holiday, particularly if you want to go abroad.

They can advise you about what you need to do to stay safe while you're away. For example, you'll need to take your usual medication and a copy of your home oxygen order form.

Before travelling, you should tell the travel company that you use oxygen as they may need to make certain arrangements in advance. Travel insurance is essential.

If you're going on holiday in the UK, talk to your oxygen supplier to see whether it's possible for oxygen to be delivered to your destination. Try to give them as much notice as possible.

The British Lung Foundation website has more information and advice about going on holiday with a lung condition. You can also read more about what you need to consider before you travel.